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Guanabenz Dosage

Applies to the following strengths: 4 mg; 8 mg

Usual Adult Dose for Hypertension

Initial dose: 4 mg orally twice a day, whether used alone or in combination with a thiazide diuretic.
Maintenance dose: 4 to 8 mg orally twice a day. The maximum dose studied is 32 mg twice a day, although doses this high are rarely needed.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Because guanabenz is extensively metabolized by the liver, it is recommended that dose increments be made cautiously in patients with liver disease.

Dose Adjustments

Titrate dosage upwards in increments of 4 to 8 mg every 1 to 2 weeks. Patients with liver impairment should have dosage adjustments made cautiously.


If to be discontinued, gradual withdrawal over 1 to 2 weeks should occur to reduce the risk of rebound hypertension.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).


Data not available

Other Comments

The maximum recommended dose is 32 mg orally twice a day (rarely needed).

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.