Femara Dosage
Generic name: LETROZOLE 2.5mg
Dosage form: tablet, film coated
Drug classes: Aromatase inhibitors, Hormones / antineoplastics
Medically reviewed by Drugs.com. Last updated on Jun 18, 2025.
Recommended Dose
The recommended dose of Femara is one 2.5 mg tablet administered once a day, without regard to meals.
Use in Adjuvant Treatment of Early Breast Cancer
In the adjuvant setting, the optimal duration of treatment with letrozole is unknown. In both the adjuvant study and the post approval adjuvant study, median treatment duration was 5 years. Treatment should be discontinued at relapse.
Use in Extended Adjuvant Treatment of Early Breast Cancer
In the extended adjuvant setting, the optimal treatment duration with Femara is not known. The planned duration of treatment in the study was 5 years. In the final updated analysis, conducted at a median follow-up of 62 months, the median treatment duration for Femara was 60 months. Seventy-one percent (71%) of patients were treated for at least 3 years and 58% of patients completed at least 4.5 years of extended adjuvant treatment. The treatment should be discontinued at tumor relapse.
Use in First and Second-Line Treatment of Advanced Breast Cancer
In patients with advanced disease, treatment with Femara should continue until tumor progression is evident.
Use in Hepatic Impairment
No dosage adjustment is recommended for patients with mild to moderate hepatic impairment, although Femara blood concentrations were modestly increased in subjects with moderate hepatic impairment due to cirrhosis. The dose of Femara in patients with cirrhosis and severe hepatic dysfunction should be reduced by 50%. The recommended dose of Femara for such patients is 2.5 mg administered every other day. The effect of hepatic impairment on Femara exposure in noncirrhotic cancer patients with elevated bilirubin levels has not been determined.
Frequently asked questions
- What are the benefits of taking Kisqali and Femara together?
- How does Femara affect your period?
- Does Femara make your hair fall out?
- Can Femara cause twins?
- When do you ovulate on Femara?
- What is the success rate for Femara in breast cancer?
- Which is better - Aromasin or Femara?
- Aromasin vs Femara - how do they compare?
- How do you take Femara? What days do you take it?
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Further information
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