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Evenity Injection Dosage

Generic name: ROMOSOZUMAB 105mg in 1.17mL
Dosage form: injection, solution
Drug class: Miscellaneous bone resorption inhibitors

Medically reviewed by Last updated on Oct 14, 2021.

Important Dosage and Administration Instructions

  • Two separate syringes (and two separate subcutaneous injections) are needed to administer the total dose of 210 mg of EVENITY. Inject two 105 mg/1.17 mL prefilled syringes, one after the other.
  • EVENITY should be administered by a healthcare provider.

Recommended Dosage

  • The recommended dose of EVENITY is 210 mg administered subcutaneously in the abdomen, thigh or upper arm. Administer EVENITY once every month.
  • The treatment duration for EVENITY is 12 monthly doses.
  • Patients should be adequately supplemented with calcium and vitamin D during treatment with EVENITY [see Warnings and Precautions (5.3) and Clinical Studies (14.1)].
  • If the EVENITY dose is missed, administer as soon as it can be rescheduled. Thereafter, EVENITY can be scheduled every month from the date of the last dose.

Preparation and Administration Instructions

Step 1: Prior to Administration:

  • Remove two syringes from the carton.
  • Visually inspect EVENITY for particles and discoloration prior to administration. EVENITY is a clear to opalescent, colorless to light yellow solution. Do not use if the solution is cloudy or discolored or contains particles.
  • Do not use the syringe if
    • any part appears cracked or broken
    • the gray needle cap is missing or not securely attached
    • the expiration date printed on the label has passed
  • Always hold the prefilled syringe by the syringe barrel to remove the syringe from the tray. See Figure A.
    • Do not grasp the plunger rod.
    • Do not grasp the gray needle cap.
    • Do not remove the gray needle cap until you are ready to inject.
  • Allow EVENITY to sit at room temperature for at least 30 minutes before injecting. Do not warm in any other way [see How Supplied/Storage and Handling (16)].

Figure A

Step 2: Select the Injection Site and Prepare the Syringe

Prepare and clean two injection sites, one for each of the two injections. See Figure B.

Figure B

The recommended subcutaneous injection sites include:
● The thigh
● Abdomen, except for a two-inch area right around the navel
● Outer area of upper arm

Clean the injection sites with alcohol wipes. Let the skin dry.
● Choose a different site each time you give an injection. If you want to use the same injection site, make sure it is not the same spot on the injection site you used for a previous injection.
● Do not inject into areas where the skin is tender, bruised, red, or hard. Avoid injecting into areas with scars or stretch marks.

Choose the first syringe. Pull the gray needle cap straight off and away from your body when you are ready to inject. See Figure C.

Figure C

● Do not put the gray needle cap back onto the syringe.

Step 3: Inject EVENITY

Insert needle and inject all the liquid subcutaneously. Do not administer into muscle or blood vessel. See Figure D.

Figure D

When done, gently lift the syringe off of the skin.

Step 4: Syringe and Needle Cap Disposal

Immediately dispose of the syringe and needle cap in the nearest sharps container.

Important: Repeat all steps with the second syringe to inject the full dose.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.