Applies to the following strength(s): 400 mg ; 600 mg
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: 600 mg orally once a day as monotherapy assuming euvolemia
Maintenance dose: 400 to 800 mg orally per day in 1 or 2 divided doses
-Maximum blood pressure reduction may take 2 to 3 weeks.
-If antihypertension measured at trough using once a day dosing is inadequate, consider twice a day dosing at the same daily dose or an increased dose.
-Limited experience exists with daily doses greater than 800 mg.
Renal Dose Adjustments
Mild renal dysfunction: No initial adjustment recommended
Moderate to severe renal dysfunction: No initial adjustment recommended; maximum dose: 600 mg/day
Liver Dose Adjustments
No initial adjustment recommended
US BOXED WARNING:
-FETAL TOXICITY: If pregnancy is detected, discontinue this drug as soon as possible. Drugs that act directly on the renin angiotensin system (RAS) can cause injury and death to the developing fetus.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
Monitoring: Assess renal function prior to therapy and periodically thereafter.
Patient advice: Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible.
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Other brands: Teveten