Dorzolamide / Timolol Ophthalmic Dosage

Usual Adult Dose for Intraocular Hypertension

1 drop in the affected eye(s) 2 times per day

Comments:
-If more than one topical ophthalmic drug is being used, the drugs should be administered at least ten minutes apart.
-The solution from one individual unit is to be used immediately after opening for administration to one or both eyes.
-The remaining contents should be discarded immediately after administration.

Use: To reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers (failed to achieve target IOP determined after multiple measurements over time)

Usual Adult Dose for Glaucoma (Open Angle)

1 drop in the affected eye(s) 2 times per day

Comments:
-If more than one topical ophthalmic drug is being used, the drugs should be administered at least ten minutes apart.
-The solution from one individual unit is to be used immediately after opening for administration to one or both eyes.
-The remaining contents should be discarded immediately after administration.

Use: To reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers (failed to achieve target IOP determined after multiple measurements over time)

Usual Pediatric Dose for Intraocular Hypertension

2 years or older:
1 drop in the affected eye(s) 2 times per day

Comments:
-If more than one topical ophthalmic drug is being used, the drugs should be administered at least ten minutes apart.
-The solution from one individual unit is to be used immediately after opening for administration to one or both eyes.
-The remaining contents should be discarded immediately after administration.

Use: To reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers (failed to achieve target IOP determined after multiple measurements over time)

Usual Pediatric Dose for Glaucoma (Open Angle)

2 years or older:
1 drop in the affected eye(s) 2 times per day

Comments:
-If more than one topical ophthalmic drug is being used, the drugs should be administered at least ten minutes apart.
-The solution from one individual unit is to be used immediately after opening for administration to one or both eyes.
-The remaining contents should be discarded immediately after administration.

Use: To reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers (failed to achieve target IOP determined after multiple measurements over time)

Renal Dose Adjustments

Mild to moderate renal impairment: Data not available
Severe renal impairment (CrCl less than 30 mL/min): Not recommended

Liver Dose Adjustments

Hepatic impairment: Use with caution

Precautions

Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Patient advice:
-Patients should be instructed to wash their hands before use and avoid allowing the tip of the container to come into contact with the eye or surrounding structures.

Storage requirements:
-Protect from light.
-Do not freeze.