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Darolutamide Dosage

Medically reviewed by Last updated on Sep 14, 2023.

Applies to the following strengths: 300 mg

Usual Adult Dose for Prostate Cancer

600 mg orally 2 times a day


Use: For nonmetastatic castration resistant prostate cancer (nmCRPC)

Renal Dose Adjustments

Mild to moderate renal impairment (CrCl 30 to 89 mL/min): No adjustment recommended.
Severe renal impairment (CrCl 15 to 29 mL/min) who are not receiving hemodialysis: 300 mg orally 2 times a day
End stage renal disease (CrCl 15 mL/min or less): Data not available

Liver Dose Adjustments

Mild (Child-Pugh A) hepatic impairment: No adjustment recommended.
Moderate (Child-Pugh B) hepatic impairment: 300 mg orally 2 times daily
Severe (Child-Pugh C) hepatic impairment: Data not available

Dose Adjustments

Grade 3 or greater toxicity or an intolerable adverse reaction: Withhold therapy or reduce to the dose to 300 mg 2 times a day until symptoms improve; then resume therapy at 600 mg orally 2 times a day.
Dose reduction below 300 mg orally 2 times a day is not recommended.



Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

Storage requirements:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.