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Darolutamide Side Effects

Medically reviewed by Last updated on Feb 22, 2024.

Applies to darolutamide: oral tablet.

Serious side effects of Darolutamide

Along with its needed effects, darolutamide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking darolutamide:

More common

Less common

Other side effects of Darolutamide

Some side effects of darolutamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common


For Healthcare Professionals

Applies to darolutamide: oral tablet.


Very common (10% or more): Neutrophil count decreased (20%), bilirubin increased (16%)[Ref]


Very common (10% or more): Pain in extremity[Ref]


Common (1% to 10%): Urinary retention, hematuria[Ref]


Very common (10% or more): AST increased (23%)[Ref]


Common (1% to 10%): Pneumonia

Uncommon (0.1% to 1%): Pulmonary embolism[Ref]


Very common (10% or more): Fatigue (16%)

Uncommon (0.1% to 1%): General physical health deterioration, death[Ref]


Uncommon (0.1% to 1%): Cardiac failure, cardiac arrest, hypertension[Ref]


Common (1% to 10%): Rash[Ref]


Uncommon (0.1% to 1%): Diarrhea, nausea[Ref]


1. (2019) "Product Information. Nubeqa (darolutamide)." Bayer HealthCare Pharmaceuticals Inc.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.