Skip to main content

Chlorthalidone / Reserpine Dosage

Applies to the following strengths: 50 mg-0.25 mg; 25 mg-0.125 mg

Usual Adult Dose for Hypertension

Initial dose: 1 tablet orally once a day (should conform to the dosages of the individual components established during titration).
Maintenance dose: 1 to 2 tablets orally once a day.

Renal Dose Adjustments

Reserpine-chlorthalidone is not recommended in patients with renal insufficiency. Chlorthalidone is not expected to be filtered into the renal tubule (its site of action) when the glomerular filtration rate is less than 10 mL/min, and the elimination half-life of reserpine may be significantly increased in patients with renal insufficiency.

Liver Dose Adjustments

Data not available

Dose Adjustments

Dosage adjustments may occur as needed every 1 to 2 weeks. Less than 15% of patients with hypertension require daily reserpine doses greater than 0.5 mg.


Data not available

Other Comments

If the antihypertensive effect associated with 2 tablets once a day is inadequate, addition of another (nondiuretic) antihypertensive agent or alternative therapy is recommended.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.