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Cefoperazone Dosage

Applies to the following strengths: 1 g; 2 g; 10 g

Usual Adult Dose for Endometritis

1 to 2 g IV or IM every 12 hours to continue until 48 hours after clinical improvement has been observed. Appropriate oral antibiotic therapy may continue until 14 days of therapy has been completed.

Usual Adult Dose for Febrile Neutropenia

1 to 2 g IV or IM every 12 hours. Therapy should be continued for 14 days, or until more specific therapy can be instituted for an identified pathogen, or until the patient has been afebrile for 24 hours after the absolute neutrophil count has reached at least 500 cells/mm3.

Usual Adult Dose for Intraabdominal Infection

1 to 2 g IV or IM every 12 hours for 7 to 14 days.

Usual Adult Dose for Joint Infection

1 to 2 g IV or IM every 12 hours for 3 to 4 weeks. Longer therapy, 6 weeks or more, may be required with prosthetic joint infections. In addition, removal of the infected joint may be required.

Usual Adult Dose for Pelvic Inflammatory Disease

1 to 2 g IV or IM every 12 hours to continue until 48 hours after clinical improvement has been observed. Appropriate oral antibiotic therapy should then commence and continue until 14 days of therapy has been completed.

Doxycycline therapy for 7 days (if not pregnant) or single dose azithromycin is also recommended to treat possible concurrent chlamydial infection.

Usual Adult Dose for Peritonitis

1 to 2 g IV or IM every 12 hours for 10 to 14 days.

Usual Adult Dose for Pneumonia

1 to 2 grams IV or IM every 12 hours for 7 to 21 days depending upon the causative organism.

Usual Adult Dose for Pyelonephritis

1 to 2 g IV or IM every 12 hours for 14 days.

Usual Adult Dose for Bacteremia

2 g IV or IM every 12 hours for 14 days.

Usual Adult Dose for Skin or Soft Tissue Infection

1 to 2 g IV or IM every 12 hours for 7 days or for 3 days after inflammation subsides depending on the nature and severity of infection. For more severe infections such as diabetic soft tissue infections, 14 to 21 days of therapy may be required.

Usual Adult Dose for Urinary Tract Infection

1 g IV or IM every 12 hours for 3 to 7 days.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

If doses greater than 4 g/24 hours are required in patients with liver disease, monitor serum levels closely.

In patients with both liver dysfunction and significant renal impairment, doses should not exceed 1 to 2 g/day without close monitoring of serum levels.

Dose Adjustments

In patients with both hepatic dysfunction and significant renal disease, dosage should not exceed 1 to 2 g/day without close monitoring of serum levels.

Precautions

If C trachomatis is a suspected pathogen, appropriate antichlamydial coverage should be added, because cefoperazone has no activity against this organism.

Patients should avoid alcoholic beverages for at least 72 hours after cefoperazone administration.

Dialysis

The half-life of cefoperazone is reduced slightly during hemodialysis. Dosing should be scheduled to follow a dialysis period.

Other Comments

When treating infections caused by Streptococcus pyogenes, therapy should be continued for at least 10 days.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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