Skip to main content

Canagliflozin / Metformin Dosage

Medically reviewed by Last updated on Aug 29, 2023.

Applies to the following strengths: 50 mg-500 mg; 50 mg-1000 mg; 150 mg-500 mg; 150 mg-1000 mg

Usual Adult Dose for Diabetes Type 2

Initial dose: Individualize dose based on patient's current regimen and renal function:

Canagliflozin-Metformin Immediate-Release tablets: Take orally twice a day with meals

Canagliflozin-Metformin Extended-release (XR tablets): Take orally once a day with morning meal

Maintenance dose: Adjust based on efficacy and tolerability; canagliflozin may be increased from 100 mg/day to 300 mg/day in patients with an eGFR of 60 mL/min/1.73 m2 or greater; a gradual dose escalation of metformin will help to reduce gastrointestinal side effects.
Maximum dose: Canagliflozin 300 mg/day; Metformin 2000 mg/day



Renal Dose Adjustments

eGFR 60 mL/min/1.73 m2 or greater: No adjustment recommended
eGFR 45 to less than 60 mL/min/1.73 m2: Maximum canagliflozin dose: 100 mg/day
eGFR 30 to less than 45 mL/min/1.73 m2: Assess benefit risk of continuing therapy; Maximum canagliflozin dose: 100 mg/day
eGFR less than 30 mL/min/1.73 m2: Contraindicated
Dialysis: Contraindicated


Liver Dose Adjustments

Metformin is not recommended in patients with clinical or laboratory evidence of hepatic disease.


Dose Adjustments

Elderly: Monitor renal function more frequently and adjust dose based on renal function.

Concomitant Use of Insulin and Insulin Secretagogues:

Concomitant use with UDP-Glucuronosyl Transferase (UGT) Enzyme Inducers, AND:

Concomitant use with drugs that increase the risk of metformin-associated lactic acidosis; impair renal function, result in significant hemodynamic changes, interfere with acid-base balance, and/or increase metformin accumulation should be undertaken with increased monitoring.

Iodinated Contrast Imaging Procedures:


Lactic Acidosis:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.



Other Comments

Administration advice:
Canagliflozin-Metformin Immediate-Release Tablets:

Missed Dose: If a dose is missed, patients should skip missed dose; patients should be advised not to take 2 doses at the same time

Canagliflozin-Metformin Extended-Release Tablets:
Missed dose: If a dose is missed, patients should take as soon as remembered unless it is almost time for the next dose, in which case, they should skip the missed dose and take at the next regularly scheduled time; patients should be advised not to take 2 doses at the same time

Storage requirements:



Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.