Skip to Content
Reach blood sugar goals with long-acting insulin. Go >

Canagliflozin / metformin Pregnancy and Breastfeeding Warnings

Canagliflozin / metformin is also known as: Invokamet, Invokamet XR

Canagliflozin / metformin Pregnancy Warnings

Animal studies have revealed that canagliflozin may affect renal development and maturation with drug exposure that correspond to the late second and third trimester of human development. Co-administration of canagliflozin and metformin in animals demonstrated that neither was embryolethal nor teratogenic, but minor skeletal abnormalities (delayed-ossification) in fetuses were observed. There are no controlled data in human pregnancy. US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Pregnancy categories A, B, C, D, and X are being phased out.

Use is not recommended. This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus. Risk Summary: Based on animal data, this drug is not recommended during the second and third trimester of pregnancy. US FDA pregnancy category: Not Assigned

See references

Canagliflozin / metformin Breastfeeding Warnings

A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Excreted into human milk: : Unknown (canagliflozin); Yes, in small amounts (metformin) Excreted into animal milk: Yes (canagliflozin, metformin) Comments: The effects in the nursing infant are unknown.

See references

References for pregnancy information

  1. "Product Information. Invokamet (canagliflozin-metFORMIN)." Janssen Pharmaceuticals, Titusville, NJ.
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

References for breastfeeding information

  1. "Product Information. Invokamet (canagliflozin-metFORMIN)." Janssen Pharmaceuticals, Titusville, NJ.
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

See Also...

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide