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Caffeine / Sodium Benzoate Dosage

Applies to the following strengths: 125 mg-125 mg/mL; 121 mg-129 mg/mL

Usual Adult Dose for Respiratory Failure

  • 500 mg via IM injection as frequently as directed by a physician.
  • Maximum Single Dose: 1 gram
  • Maximum Total Dose in 24 Hours: Should rarely exceed 2.5 grams

  • Administer via slow IV injection in emergency respiratory failure cases.
  • 500 mg of this drug contains about 250 mg of anhydrous caffeine.
  • Analeptic use of caffeine is strongly discouraged by most clinicians because of questionable benefit and transient action.

Use: In conjunction with supportive measures, treatment for respiratory depression associated with overdosage of CNS depressants (e.g., narcotic analgesics, alcohol) and with electric shock.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available


Safety and efficacy have not been established, and this drug and the manufacturer labeling have not been approved by the FDA.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Storage Requirements:

  • Store at 20 to 25 degrees Celsius (68 to 77 Fahrenheit).

  • IV doses of 57 mg/kg and oral doses of 18.5 grams have been fatal in adults.
  • Convulsions caused by overdosage may be treated with IV diazepam or a barbiturate (e.g., pentobarbital sodium).

More about caffeine / sodium benzoate

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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.