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Caffeine / sodium benzoate Side Effects

For the Consumer

Applies to caffeine / sodium benzoate: injection solution

In addition to its needed effects, some unwanted effects may be caused by caffeine / sodium benzoate. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking caffeine / sodium benzoate, check with your doctor or nurse immediately:

Incidence not known:
  • Extra heartbeats
  • fast, pounding, or irregular heartbeat or pulse
  • trembling or shaking of the hands or feet

If any of the following symptoms of overdose occur while taking caffeine / sodium benzoate, get emergency help immediately:

Symptoms of overdose:
  • Chest pain or discomfort
  • confusion
  • confusion as to time, place, or person
  • decreased urination
  • dizziness
  • dry mouth
  • fainting
  • fever
  • hallucinations
  • holding false beliefs that cannot be changed by fact
  • increase in heart rate
  • lightheadedness
  • pounding or rapid pulse
  • rapid breathing
  • sleeplessness
  • slow heartbeat
  • sunken eyes
  • thirst
  • trouble sleeping
  • unable to sleep
  • unusual excitement, nervousness, or restlessness
  • unusual tiredness or weakness
  • wrinkled skin

Minor Side Effects

Some of the side effects that can occur with caffeine / sodium benzoate may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:
  • Anxiety
  • continuing ringing or buzzing or other unexplained noise in the ears
  • headache
  • hearing loss
  • hyperventilation
  • increased sensitivity to pain
  • increased sensitivity to touch
  • irritability
  • restlessness
  • shortness of breath
  • tingling in the hands and feet
  • trouble sleeping

For Healthcare Professionals

Applies to caffeine / sodium benzoate: injectable solution


Large doses of caffeine may cause headache, excitement, agitation, scintillating scotoma, hyperesthesia, tinnitus, muscle tremors or twitches, diuresis, tachycardia, extrasystoles, other cardiac arrhythmias, and a condition resembling anxiety neurosis.[Ref]


1. "Product Information. Caffeine-Sodium Benzoate (caffeine-sodium benzoate)." American Regent Laboratories Inc, Shirley, NY.

Not all side effects for caffeine / sodium benzoate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.