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Caffeine / sodium benzoate Side Effects

For the Consumer

Applies to caffeine / sodium benzoate: injection solution

Along with its needed effects, caffeine/sodium benzoate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking caffeine / sodium benzoate:

Incidence not known
  • Extra heartbeats
  • fast, pounding, or irregular heartbeat or pulse
  • trembling or shaking of the hands or feet

Get emergency help immediately if any of the following symptoms of overdose occur while taking caffeine / sodium benzoate:

Symptoms of overdose
  • Chest pain or discomfort
  • confusion
  • confusion as to time, place, or person
  • decreased urination
  • dizziness
  • dry mouth
  • fainting
  • fever
  • hallucinations
  • holding false beliefs that cannot be changed by fact
  • increase in heart rate
  • lightheadedness
  • pounding or rapid pulse
  • rapid breathing
  • sleeplessness
  • slow heartbeat
  • sunken eyes
  • thirst
  • trouble sleeping
  • unable to sleep
  • unusual excitement, nervousness, or restlessness
  • unusual tiredness or weakness
  • wrinkled skin

Some side effects of caffeine / sodium benzoate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Anxiety
  • continuing ringing or buzzing or other unexplained noise in the ears
  • headache
  • hearing loss
  • hyperventilation
  • increased sensitivity to pain
  • increased sensitivity to touch
  • irritability
  • restlessness
  • shortness of breath
  • tingling in the hands and feet
  • trouble sleeping

For Healthcare Professionals

Applies to caffeine / sodium benzoate: injectable solution


Large doses of caffeine may cause headache, excitement, agitation, scintillating scotoma, hyperesthesia, tinnitus, muscle tremors or twitches, diuresis, tachycardia, extrasystoles, other cardiac arrhythmias, and a condition resembling anxiety neurosis.[Ref]


1. "Product Information. Caffeine-Sodium Benzoate (caffeine-sodium benzoate)." American Regent Laboratories Inc, Shirley, NY.

Some side effects of caffeine / sodium benzoate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.