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Atorvastatin / Ezetimibe Dosage

Applies to the following strength(s): 10 mg-10 mg ; 20 mg-10 mg ; 40 mg-10 mg ; 80 mg-10 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hyperlipidemia

Initial dose: Atorvastatin-ezetimibe 10/10 or 20/10 mg orally once daily
Initial dose for patients who require a larger reduction in LDL-C (greater than 55%): Atorvastatin-ezetimibe 40/10 mg orally once daily
Titration: After initiation and/or upon titration of atorvastatin-ezetimibe, lipid levels should be analyzed within 2 or more weeks and dosage adjusted accordingly.

Patients with Homozygous Familial Hypercholesterolemia:
Dosage: Atorvastatin-ezetimibe 40/10 or 80/10
Comments: Atorvastatin-ezetimibe should be used as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) in these patients or if such treatments are unavailable.

Approved indications:
Indicated as adjunctive therapy to diet to:
-Reduce elevated total-C, LDL-C, Apo B, TG, and non-HDL-C, and to increase HDL-C in patients with primary (heterozygous familial and nonfamilial) hyperlipidemia or mixed hyperlipidemia.
-Reduce elevated total-C and LDL-C in patients with homozygous familial hypercholesterolemia (HoFH), as an adjunct to other lipid-lowering treatments.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Atorvastatin-ezetimibe is contraindicated in patients with active liver disease or unexplained persistent elevations in hepatic transaminase levels.

Dose Adjustments

Dosing of atorvastatin-ezetimibe should occur either 2 or more hours before or 4 or more hours after administration of a bile acid sequestrant.

Drug interactions associated with increased risk of myopathy/rhabdomyolysis with atorvastatin:
-Cyclosporine, HIV protease inhibitors (tipranavir plus ritonavir), hepatitis C protease inhibitor (telaprevir), gemfibrozil: Avoid atorvastatin-ezetimibe.
-HIV protease inhibitor (lopinavir plus ritonavir): Use atorvastatin-ezetimibe with caution and the lowest dose necessary.
-Clarithromycin, itraconazole, HIV protease inhibitors (saquinavir plus ritonavir, darunavir plus ritonavir, fosamprenavir, fosamprenavir plus ritonavir: Do not exceed atorvastatin-ezetimibe 20/10 mg daily.
-HIV protease inhibitor (boceprevir): Do not exceed atorvastatin-ezetimibe 40/10 mg daily.

Dialysis

Atorvastatin: Hemodialysis is not expected to significantly enhance clearance of atorvastatin since the drug is extensively bound to plasma proteins.

Ezetimibe: Data not available

Other Comments

No incremental benefit of atorvastatin-ezetimibe on cardiovascular morbidity and mortality over and above that demonstrated for atorvastatin has been established.

Atorvastatin-ezetimibe has not been studied in Fredrickson Type I, III, IV, and V dyslipidemia.

Dosing of atorvastatin-ezetimibe should occur either 2 or more hours before or 4 or more hours after administration of a bile acid sequestrant.

Atorvastatin-ezetimibe can be taken at any time of the day with or without food.

Tablets should be swallowed whole, not chewed, crushed, or dissolved.

Grapefruit juice contains one or more components that inhibit CYP450 3A4 and can increase plasma concentrations of atorvastatin, especially with excessive grapefruit juice consumption (1.2 liters or more per day).

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