Aspirin / Diphenhydramine Dosage

Applies to the following strengths: 500 mg-38.3 mg

Usual Adult Dose for Pain

2 caplets at bedtime, if needed, or as directed by a doctor

Usual Adult Dose for Headache

2 caplets at bedtime, if needed, or as directed by a doctor

Usual Pediatric Dose for Pain

<12 years
Do not use.

>=12 years
2 caplets at bedtime, if needed, or as directed by a doctor

Usual Pediatric Dose for Headache

<12 years
Do not use.

>=12 years
2 caplets at bedtime, if needed, or as directed by a doctor

Renal Dose Adjustments

Detailed information concerning the pharmacokinetic disposition of aspirin in patients with renal dysfunction is not available. Aspirin should be used with caution in chronic renal insufficiency, since it may cause a transient decrease in renal function. The use of aspirin in patients with severe renal impairment (CrCl <10 mL/minute) is not recommended due to the potential for increased risk of salicylate toxicity.

Liver Dose Adjustments

The use of aspirin in patients with severe hepatic impairment is not recommended due to the potential for increased risk of clinically significant bleeding and other adverse effects.

Precautions

Do not exceed recommended dosage.

Aspirin should not be used in children or adolescents with chickenpox or influenza symptoms due to the association with Reye's syndrome.

Patients should be warned of the sedative effects of diphenhydramine, and advised not to take this drug with alcohol.

Due to the anticholinergic effect of diphenhydramine, it should be used with caution in patients with narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, prostatic hypertrophy or bladder neck obstructions. It should also be used with caution in patients with increased intraocular pressure, hyperthyroidism, cardiovascular disease, or hypertension.

Dialysis

Detailed information concerning the removal of aspirin by hemodialysis is not available. Some investigators have suggested that aspirin and/or salicylate may be removed by hemodialysis.