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Aspirin / Butalbital / Caffeine / Codeine Dosage

Applies to the following strength(s): 325 mg-50 mg-40 mg-30 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Headache

1 or 2 capsules orally every 4 hours as needed not to exceed 6 capsules per day

Comments:
-Due to high rate of physical dependence, the extended use of this drug is not recommended.
-The safety and efficacy of treating multiple recurrent headaches with this product is not known.

Uses: For the relief of the symptom complex of tension (or muscle contraction) headache.

Renal Dose Adjustments

Use with caution

Liver Dose Adjustments

Use with caution

Dose Adjustments

Elderly: Dose selection should be cautious, usually starting at the low end of the dose range.

The drug should not be abruptly discontinued in the physically dependent person.

Precautions

US BOXED WARNING: DEATH RELATED TO ULTRA-RAPID METABOLISM OF CODEINE TO MORPHINE
-Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being an ultra-rapid metabolizer of codeine due to a CYP2D6 polymorphism.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule III

Dialysis

Data not available

Other Comments

Administration advice:
-Take orally as needed
-Do not exceed 6 capsules per day

Storage requirements: Protect from light and moisture

General:
-Butalbital and codeine are drugs that may be abused; extended use is not recommended.

Monitoring:
-Monitor for potential abuse
-Monitor for respiratory depression and signs of morphine overdose
-Monitor liver function tests in patients with severe hepatic disease
-Monitor renal function tests in patients with severe renal disease

Patient advice:
-Patients should be advised that this drug has the potential to cause physical and psychological dependence, and tolerance; patients should be instructed to take this drug as prescribed, in the amounts prescribed, and no more frequently than prescribed.
-Patients should understand the risks of life-threatening respiratory depression and when this risk is greatest, patients should be aware that a genetic mutation may result in greater toxicity in some patients.
-Patients should understand that this drug contains aspirin and should not be taken by patients with an allergy or sensitivity to aspirin.
-Patients should be advised to avoid alcohol and performance of potentially hazardous tasks (such as driving a car) while taking this drug.
-Women of childbearing potential should be advised to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

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