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Aspirin / Butalbital / Caffeine / Codeine Dosage

Applies to the following strength(s): 325 mg-50 mg-40 mg-30 mg

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for Headache

1 or 2 capsules orally every 4 hours as needed not to exceed 6 capsules per day

-Due to high rate of physical dependence, the extended use of this drug is not recommended.
-The safety and efficacy of treating multiple recurrent headaches with this product is not known.

Uses: For the relief of the symptom complex of tension (or muscle contraction) headache.

Renal Dose Adjustments

Use with caution

Liver Dose Adjustments

Use with caution

Dose Adjustments

Elderly: Dose selection should be cautious, usually starting at the low end of the dose range.

The drug should not be abruptly discontinued in the physically dependent person.


-Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being an ultra-rapid metabolizer of codeine due to a CYP2D6 polymorphism.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule III


Data not available

Other Comments

Administration advice:
-Take orally as needed
-Do not exceed 6 capsules per day

Storage requirements: Protect from light and moisture

-Butalbital and codeine are drugs that may be abused; extended use is not recommended.

-Monitor for potential abuse
-Monitor for respiratory depression and signs of morphine overdose
-Monitor liver function tests in patients with severe hepatic disease
-Monitor renal function tests in patients with severe renal disease

Patient advice:
-Patients should be advised that this drug has the potential to cause physical and psychological dependence, and tolerance; patients should be instructed to take this drug as prescribed, in the amounts prescribed, and no more frequently than prescribed.
-Patients should understand the risks of life-threatening respiratory depression and when this risk is greatest, patients should be aware that a genetic mutation may result in greater toxicity in some patients.
-Patients should understand that this drug contains aspirin and should not be taken by patients with an allergy or sensitivity to aspirin.
-Patients should be advised to avoid alcohol and performance of potentially hazardous tasks (such as driving a car) while taking this drug.
-Women of childbearing potential should be advised to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.