Anistreplase Dosage

Usual Adult Dose for Myocardial Infarction

30 units IV once over 2 to 5 minutes.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Other Comments

Patients treated within 1 to 3 hours of the onset of symptoms benefit most. Heparin may be used following anistreplase in order to maintain vessel patency.

Potency is expressed in units of anistreplase by using a reference standard which is unique to anistreplase and is not comparable to units used for other fibrinolytics.

Although anistreplase has not been extensively studied in the treatment of ischemic stroke, according to AHA/ASA guidelines for the early management of ischemic stroke, use of a thrombolytic agent (i.e., recombinant tissue plasminogen activator; alteplase) within 3 hours of stroke symptom onset is associated with improved outcomes. Earlier treatment (i.e., within 90 minutes) may be more likely to result in a favorable outcome. However, the upper limit of the treatment window may be as late as 5 to 6 hours after symptom onset.

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Further information

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