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Alogliptin / Metformin Dosage

Medically reviewed by Drugs.com. Last updated on Mar 21, 2023.

Applies to the following strengths: 12.5 mg-500 mg; 12.5 mg-1000 mg

Usual Adult Dose for Diabetes Type 2

Individualize initial dose based on patients current regimen; metformin dose should be gradually titrated upwards and taken with food to reduce the gastrointestinal side effects:

Initial dose: alogliptin 12.5 mg-metformin 500 mg OR alogliptin 12.5 mg-metformin 1000 mg orally twice a day
Maintenance dose: Adjust dose based on efficacy and tolerability
Maximum dose: alogliptin 25 mg-metformin 2000 mg per day

Comments:


Use: As an adjunct to diet and exercise, to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both alogliptin and metformin is appropriate.

Renal Dose Adjustments

Mild renal impairment (eGFR greater than 60 mL/min/1.73 m2): No dose adjustments recommended
Moderate renal impairment (eGFR 30 to 60 mL/min/1.73 m2): Not recommended because alogliptin dose in combination product is not appropriate
Severe renal impairment (estimated GFR less than 30 mL/min/1.73 m2): Contraindicated

IODINATED CONTRAST PROCEDURE:

Liver Dose Adjustments

Hepatic impairment: Use not recommended

Dose Adjustments

Elderly: No dose adjustment is necessary based on age; however, ensure adequate renal function before initiating therapy.

Due to risk of hypoglycemia if used in combination with insulin, or insulin secretagogue such as a sulfonylurea, a lower dose of insulin, or insulin secretagogue should be considered to decrease the risk of hypoglycemia.

IODINATED CONTRAST PROCEDURE:

Precautions

US BOXED WARNING: LACTIC ACIDOSIS


CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.