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Aliskiren Dosage

Applies to the following strength(s): 150 mg ; 300 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial: 150 mg orally once a day
Maintenance: the dosage may be increased to 300 mg daily if blood pressure is not adequately controlled.

Comments:
-The antihypertensive effect is substantially attained by 2 weeks.
-Tablets should be taken the same way each day, either with or without a meal. (High-fat meals decrease absorption of aliskiren substantially).
Aliskiren may be used alone or in combination with other antihypertensive agents.

Renal Dose Adjustments

Mild to moderate renal dysfunction (CrCl 30 mL/min or greater): No adjustment recommended
Severe renal dysfunction (CrCl 30 mL/min or less): Not recommended

Liver Dose Adjustments

No adjustment recommended

Dose Adjustments

No dosage adjustment is recommended based on gender, age, body weight, or race..

Precautions

BOXED WARNING(S):
-If pregnancy is detected, discontinue aliskiren as soon as possible.
-Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

-Patients should establish a routine pattern for taking aliskiren either with or without a meal. High-fat meals decrease absorption of aliskiren substantially.
-Periodic monitoring of serum electrolytes and renal function is recommended, particularly in patients with diabetes mellitus, renal dysfunction, or heart failure.
-Aliskiren is effective alone and in combination with other antihypertensive agents.

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