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Aliskiren / Hydrochlorothiazide Dosage

Medically reviewed by Drugs.com. Last updated on Aug 14, 2023.

Applies to the following strengths: 150 mg-12.5 mg; 150 mg-25 mg; 300 mg-12.5 mg; 300 mg-25 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: 150 mg-12.5 mg or 150 mg-25 mg once daily

Maximum dose: Aliskiren-hydrochlorothiazide 300/25 mg orally daily

Comments:

Renal Dose Adjustments

CrCl less than 30 mL/min: Not recommended

CrCl greater than 30 mL/min: No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Precautions

US BOXED WARNING:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice: Patients should establish a routine pattern for taking aliskiren-hydrochlorothiazide, either with or without a meal. High-fat meals decrease absorption of aliskiren substantially.

Patient advice: Instruct patients to protect skin from sun and undergo regular skin cancer screening.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.