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Aliskiren / Hydrochlorothiazide Dosage

Medically reviewed by Last updated on Aug 14, 2023.

Applies to the following strengths: 150 mg-12.5 mg; 150 mg-25 mg; 300 mg-12.5 mg; 300 mg-25 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: 150 mg-12.5 mg or 150 mg-25 mg once daily

Maximum dose: Aliskiren-hydrochlorothiazide 300/25 mg orally daily


  • The combination product may be substituted for patients receiving aliskiren and hydrochlorothiazide from separate tablets.
  • Tablets should be taken the same way each day, either with or without a meal. (High-fat meals decrease absorption of aliskiren substantially).

Renal Dose Adjustments

CrCl less than 30 mL/min: Not recommended

CrCl greater than 30 mL/min: No adjustment recommended

Liver Dose Adjustments

No adjustment recommended



  • FETAL TOXICITY: If pregnancy is detected, discontinue aliskiren-hydrochlorothiazide as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice: Patients should establish a routine pattern for taking aliskiren-hydrochlorothiazide, either with or without a meal. High-fat meals decrease absorption of aliskiren substantially.

Patient advice: Instruct patients to protect skin from sun and undergo regular skin cancer screening.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.