Aliskiren / Amlodipine Dosage
Applies to the following strength(s): 150 mg-5 mg ; 150 mg-10 mg ; 300 mg-5 mg ; 300 mg-10 mg
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Usual Adult Dose for:
Usual Geriatric Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial or add-on therapy: 150 mg/5 mg orally once a day. Titrate as needed up to a maximum of 300 mg/10 mg.
The blood pressure lowering effect is largely attained within 1 to 2 weeks.
Maximum dose: 300 mg/10 mg
-The combination product may be substituted for patients receiving aliskiren and amlodipine from separate tablets.
-Tablets should be taken the same way each day, either with or without a meal. (High-fat meals decrease absorption of aliskiren substantially).
Usual Geriatric Dose for Hypertension
Exposure to aliskiren and amlodipine is increased in elderly patients. Lower initial doses of aliskiren-amlodipine should be considered.
Renal Dose Adjustments
CrCl less than 30 mL/min: Not recommended
Liver Dose Adjustments
Exposure to amlodipine is increased in patients with hepatic insufficiency. Lower doses should be considered in these patients.
-Aliskiren-amlodipine may be used for patients not adequately controlled with aliskiren alone or amlodipine (or another dihydropyridine calcium channel blocker) alone.
-A patient who experiences dose-limiting adverse reactions attributed to an individual component while on any dual combination of the components of aliskiren-amlodipine may be switched to aliskiren-amlodipine at a lower dose of that component to achieve similar blood pressure reductions.
-For patients receiving aliskiren and amlodipine from separate tablets, aliskiren-amlodipine may be substituted containing the same component doses.
-If pregnancy is detected, discontinue aliskiren/amlodipine/hydrochlorothiazide as soon as possible.
-Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
Patients should establish a routine pattern for taking aliskiren-amlodipine, either with or without a meal. High-fat meals decrease absorption of aliskiren substantially.
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Other brands: Tekamlo