Aliskiren / Amlodipine / Hydrochlorothiazide Dosage
Applies to the following strengths: 150 mg-5 mg-12.5 mg; 300 mg-5 mg-12.5 mg; 300 mg-5 mg-25 mg; 300 mg-10 mg-12.5 mg; 300 mg-10 mg-25 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: 1 tablet orally daily
The dosage may be increased after 2 weeks of therapy.
Maximum dose: Aliskiren/amlodipine/hydrochlorothiazide 300/10/25 mg orally daily
Comments:
- The combination product may be substituted for patients receiving aliskiren, amlodipine, and hydrochlorothiazide from separate tablets.
- Tablets should be taken the same way each day, either with or without a meal. (High-fat meals decrease absorption of aliskiren substantially).
Renal Dose Adjustments
CrCl less than 30 mL/min: Not recommended
CrCl greater than 30 mL/min: No adjustment recommended
Liver Dose Adjustments
Exposure to amlodipine is increased in patients with hepatic insufficiency. Lower doses should be considered in these patients.
Dose Adjustments
- Aliskiren/amlodipine/hydrochlorothiazide may be used for patients not adequately controlled with any two of the following: aliskiren, dihydropyridine calcium channel blockers, and thiazide diuretics.
- A patient who experiences dose-limiting adverse reactions attributed to an individual component while on any dual combination of the components of aliskiren/amlodipine/hydrochlorothiazide may be switched to aliskiren/amlodipine/hydrochlorothiazide at a lower dose of that component to achieve similar blood pressure reductions.
- For patients receiving aliskiren, amlodipine, and hydrochlorothiazide from separate tablets, aliskiren/amlodipine/hydrochlorothiazide may be substituted containing the same component doses.
Precautions
US BOXED WARNING:
- FETAL TOXICITY: If pregnancy is detected, discontinue aliskiren/amlodipine/hydrochlorothiazide as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Patients should establish a routine pattern for taking aliskiren/amlodipine/hydrochlorothiazide, either with or without a meal. High-fat meals decrease absorption of aliskiren substantially.
More about aliskiren / amlodipine / hydrochlorothiazide
- Check interactions
- Compare alternatives
- Side effects
- During pregnancy
- Drug class: miscellaneous antihypertensive combinations
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
