Aliskiren / Amlodipine / Hydrochlorothiazide Dosage
Applies to the following strength(s): 150 mg-5 mg-12.5 mg ; 300 mg-5 mg-12.5 mg ; 300 mg-5 mg-25 mg ; 300 mg-10 mg-12.5 mg ; 300 mg-10 mg-25 mg
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: 1 tablet orally daily
The dosage may be increased after 2 weeks of therapy.
Maximum dose: Aliskiren/amlodipine/hydrochlorothiazide 300/10/25 mg orally daily
-The combination product may be substituted for patients receiving aliskiren, amlodipine, and hydrochlorothiazide from separate tablets.
-Tablets should be taken the same way each day, either with or without a meal. (High-fat meals decrease absorption of aliskiren substantially).
Renal Dose Adjustments
CrCl less than 30 mL/min: Not recommended
CrCl greater than 30 mL/min: No adjustment recommended
Liver Dose Adjustments
Exposure to amlodipine is increased in patients with hepatic insufficiency. Lower doses should be considered in these patients.
-Aliskiren/amlodipine/hydrochlorothiazide may be used for patients not adequately controlled with any two of the following: aliskiren, dihydropyridine calcium channel blockers, and thiazide diuretics.
-A patient who experiences dose-limiting adverse reactions attributed to an individual component while on any dual combination of the components of aliskiren/amlodipine/hydrochlorothiazide may be switched to aliskiren/amlodipine/hydrochlorothiazide at a lower dose of that component to achieve similar blood pressure reductions.
-For patients receiving aliskiren, amlodipine, and hydrochlorothiazide from separate tablets, aliskiren/amlodipine/hydrochlorothiazide may be substituted containing the same component doses.
-If pregnancy is detected, discontinue aliskiren/amlodipine/hydrochlorothiazide as soon as possible.
-Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
Patients should establish a routine pattern for taking aliskiren/amlodipine/hydrochlorothiazide, either with or without a meal. High-fat meals decrease absorption of aliskiren substantially.
More about aliskiren/amlodipine/hydrochlorothiazide
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- Drug class: miscellaneous antihypertensive combinations
- Aliskiren, amlodipine, and hydrochlorothiazide
- Aliskiren, amlodipine, and hydrochlorothiazide (Advanced Reading)
Other brands: Amturnide