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Aliskiren / Amlodipine / Hydrochlorothiazide Dosage

Applies to the following strengths: 150 mg-5 mg-12.5 mg; 300 mg-5 mg-12.5 mg; 300 mg-5 mg-25 mg; 300 mg-10 mg-12.5 mg; 300 mg-10 mg-25 mg

Usual Adult Dose for Hypertension

Initial dose: 1 tablet orally daily
The dosage may be increased after 2 weeks of therapy.

Maximum dose: Aliskiren/amlodipine/hydrochlorothiazide 300/10/25 mg orally daily


Renal Dose Adjustments

CrCl less than 30 mL/min: Not recommended

CrCl greater than 30 mL/min: No adjustment recommended

Liver Dose Adjustments

Exposure to amlodipine is increased in patients with hepatic insufficiency. Lower doses should be considered in these patients.

Dose Adjustments



Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Patients should establish a routine pattern for taking aliskiren/amlodipine/hydrochlorothiazide, either with or without a meal. High-fat meals decrease absorption of aliskiren substantially.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.