Acetaminophen / Dextromethorphan / Pseudoephedrine Dosage

Applies to the following strengths: 500 mg-20 mg-60 mg/15 mL; 1000 mg-30 mg-60 mg; 500 mg-15 mg-30 mg; 160 mg-7.5 mg-15 mg/5 mL; 650 mg-30 mg-60 mg; 325 mg-15 mg-30 mg; 650 mg-30 mg-60 mg/15 mL; 160 mg-5 mg-15 mg/1.6 mL; 160 mg-5 mg-15 mg; 250 mg-10 mg-30 mg; 650 mg-20 mg-60 mg/30 mL; 325 mg-10 mg-30 mg; 1000 mg-30 mg-60 mg/30 mL

Usual Adult Dose for Cold Symptoms

acetaminophen/dextromethorphan/pseudoephedrine 1000 mg-30 mg-60 mg /30 mL oral liquid:
30 mL orally every 6 hours not to exceed 4 doses daily.

acetaminophen/dextromethorphan/pseudoephedrine 325 mg-15 mg-30 mg oral capsule:
2 capsules orally with water every 6 hours not to exceed 8 capsules daily.

Usual Pediatric Dose for Cold Symptoms

acetaminophen/dextromethorphan/pseudoephedrine 1000 mg-30 mg-60 mg /30 mL oral liquid:
12 yrs or older: 30 mL orally every 6 hours not to exceed 4 doses daily.

acetaminophen/dextromethorphan/pseudoephedrine 325 mg-15 mg-30 mg oral capsule:
12 yrs or older: 2 capsules with water every 6 hours not to exceed 8 capsules daily.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

The FDA has not approved use of over-the-counter cough and cold medications to children aged less than 2 years, and proper dosing for children in this age group has not been studied. Clinicians should be aware of the risk for serious illness or fatal overdose from administration of cough and cold medications to children aged less than 2 years. Clinicians should be certain that caregivers understand 1) the importance of administering cough and cold medications only as directed and 2) the risk for overdose if they administer additional medications that might contain the same ingredient.