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Erivedge (vismodegib) Disease Interactions

There is 1 disease interaction with Erivedge (vismodegib):


Hedgehog Pathway Inhibitors (Includes Erivedge) ↔ Musculoskeletal Disorders

Moderate Potential Hazard, Moderate plausibility

Applies to: History - Musculoskeletal Disorder

Musculoskeletal adverse reactions, which may be accompanied by serum creatine kinase elevations have been reported with the use of drugs that inhibit the hedgehog pathway. It is recommended to obtain serum creatine kinase levels and renal function tests prior to initiating therapy, periodically during treatment, and as clinically indicated. Care should be taken when prescribing these agents to patients presenting musculoskeletal pain or myalgia. Temporary dose interruption or discontinuation of therapy may be required based on the severity of musculoskeletal adverse reactions.

Erivedge (vismodegib) drug Interactions

There are 120 drug interactions with Erivedge (vismodegib)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.