Erivedge Disease Interactions
There is 1 disease interaction with Erivedge (vismodegib).
Hedgehog pathway inhibitors (applies to Erivedge) musculoskeletal disorders
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: History - Musculoskeletal Disorder
Musculoskeletal adverse reactions, which may be accompanied by serum creatine kinase elevations have been reported with the use of drugs that inhibit the hedgehog pathway. It is recommended to obtain serum creatine kinase levels and renal function tests prior to initiating therapy, periodically during treatment, and as clinically indicated. Care should be taken when prescribing these agents to patients presenting musculoskeletal pain or myalgia. Temporary dose interruption or discontinuation of therapy may be required based on the severity of musculoskeletal adverse reactions.
- "Product Information. Odomzo (sonidegib)." Novartis Pharmaceuticals (2015):
Erivedge drug interactions
There are 59 drug interactions with Erivedge (vismodegib).
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- Drug class: hedgehog pathway inhibitors
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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