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Incruse Ellipta Disease Interactions

There are 3 disease interactions with Incruse Ellipta (umeclidinium).


Inhaled anticholinergic bronchodilators (applies to Incruse Ellipta) milk protein allergies

Major Potential Hazard, Moderate plausibility. Applicable conditions: Lactose Intolerance

Some inhaled anticholinergic bronchodilators such as aclidinium and umeclidinium are contraindicated in patients with severe hypersensitivity to milk proteins. There have been reports of anaphylactic reactions on these patients after inhalation of other powder products containing lactose, therefore patients with severe milk protein allergy should not use these products.


  1. "Product Information. Tudorza Pressair (aclidinium)." Forest Pharmaceuticals (2012):
  2. "Product Information. Incruse Ellipta (umeclidinium)." GlaxoSmithKline (2014):

Inhaled anticholinergic agents (applies to Incruse Ellipta) anticholinergic effects

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Urinary Retention, Glaucoma (Narrow Angle)

Aclidinium, ipratropium, umeclidinium, and tiotropium are anticholinergic agents. Although systemic effects are uncommon due to the poor absorption of quaternary ammonium compounds from gastrointestinal and nasal mucosa, worsening of urinary retention or angle-closure glaucoma has been reported. Increased intraocular pressure and precipitation or exacerbation of angle-closure glaucoma may also occur due to inadvertent contact of the eye with aerosolized or nebulized drug. Accordingly, therapy with quaternary ammonium compounds should be administered cautiously in patients with urinary retention/obstruction or angle-closure glaucoma. Measures should be taken whenever possible to minimize ocular exposure to these drugs, such as keeping eyes closed during oral inhalation or use of a mouthpiece rather than face mask during nebulization. Patients should be advised to contact their physician if they experience urinary difficulty (especially in patients with prostatic hyperplasia or bladder neck obstruction); or signs and symptoms of angle-closure glaucoma (e.g., eye pain or discomfort; blurred vision; visual halos; colored images in association with red eyes from conjunctival congestion or corneal edema).


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  7. "Product Information. Atrovent (ipratropium)." Boehringer-Ingelheim (2002):
  8. "Product Information. Atrovent Nasal (ipratropium nasal)." Boehringer-Ingelheim
  9. "Product Information. Spiriva (tiotropium)." Boehringer Ingelheim (2002):
  10. "Product Information. Tudorza Pressair (aclidinium)." Forest Pharmaceuticals (2012):
  11. "Product Information. Incruse Ellipta (umeclidinium)." GlaxoSmithKline (2014):
View all 11 references

Umeclidinium (applies to Incruse Ellipta) severe liver impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Patients with moderate hepatic impairment showed no relevant increases in Cmax or AUC when using umeclidinium, when compared with healthy subjects. However, studies have not been performed in patients with severe hepatic impairment.


  1. "Product Information. Incruse Ellipta (umeclidinium)." GlaxoSmithKline (2014):

Incruse Ellipta drug interactions

There are 101 drug interactions with Incruse Ellipta (umeclidinium).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.