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Benzacot (trimethobenzamide) Disease Interactions

There are 3 disease interactions with Benzacot (trimethobenzamide):

Major

Trimethobenzamide (Includes Benzacot) ↔ Reye's Syndrome

Severe Potential Hazard, High plausibility

Applies to: Reye's Syndrome

The use of trimethobenzamide should be avoided in children and adolescents whose signs and symptoms suggest Reye's syndrome. The extrapyramidal symptoms which can occur secondary to trimethobenzamide use may confound the diagnosis of Reye's syndrome. In addition, drugs with hepatotoxic potential such as trimethobenzamide may adversely affect the course of Reye's syndrome.

References

  1. Holmes C, Flaherty RJ "Trimethobenzamide HCL (Tigan)-induced extrapyramidal dysfunction in a neonate." J Pediatr 89 (1976): 669-70
  2. "Product Information. Tigan (trimethobenzamide)." Monarch Pharmaceuticals Inc, Bristol, TN.
Moderate

Trimethobenzamide (Includes Benzacot) ↔ Parkinsonism

Moderate Potential Hazard, High plausibility

Applies to: Parkinsonism

The use of trimethobenzamide has been associated with pseudo- parkinsonian reactions including mask- like faces, drooling, cogwheel rigidity, and shuffling gait. Therapy with trimethobenzamide should be administered cautiously in patients with parkinsonism.

References

  1. "Product Information. Tigan (trimethobenzamide)." Monarch Pharmaceuticals Inc, Bristol, TN.
Moderate

Trimethobenzamide (Includes Benzacot) ↔ Renal Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

Trimethobenzamide is mostly eliminated by the kidneys and a dosage adjustment should be considered in patients with reduced renal function (creatinine clearance <= 70 mL/min), including some elderly patients.

Benzacot (trimethobenzamide) drug Interactions

There are 563 drug interactions with Benzacot (trimethobenzamide)

Benzacot (trimethobenzamide) alcohol/food Interactions

There is 1 alcohol/food interaction with Benzacot (trimethobenzamide)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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