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Tolterodine Disease Interactions

There are 7 disease interactions with tolterodine:

Major

Tolterodine (applies to tolterodine) angle-closure glaucoma

Major Potential Hazard, High plausibility. Applicable conditions: Glaucoma/Intraocular Hypertension

The use of tolterodine is contraindicated in patients with uncontrolled angle-closure (narrow angle) glaucoma. Tolterodine exerts anticholinergic activity and can result in increased intraocular pressure and loss of accommodation.

References

  1. "Product Information. Detrol (tolterodine)." Pharmacia and Upjohn, Kalamazoo, MI.
Major

Tolterodine (applies to tolterodine) GI/urinary obstruction

Major Potential Hazard, High plausibility. Applicable conditions: Urinary Retention, Gastrointestinal Obstruction

The use of tolterodine is contraindicated in patients with GI obstruction, ileus, or obstructive uropathy. Tolterodine exerts anticholinergic activity by competitive antagonism of muscarinic receptors.

References

  1. "Product Information. Detrol (tolterodine)." Pharmacia and Upjohn, Kalamazoo, MI.
Moderate

Tolterodine (applies to tolterodine) CNS

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Dementia, CNS Disorder

Tolterodine is associated with anticholinergic central nervous system (CNS) effects. If a patient experiences anticholinergic CNS effects, dose reduction or drug discontinuation should be considered. Tolterodine should be used with caution in patients with Parkinson's disease and in patients with preexisting dementia treated with cholinesterase inhibitors due to the risk of aggravation of symptoms.

Moderate

Tolterodine (applies to tolterodine) hepatic dysfunction

Moderate Potential Hazard, High plausibility. Applicable conditions: Liver Disease

Tolterodine undergoes biotransformation in the liver of extensive metabolizers to an active metabolite. Poor metabolizers have a greater concentration of active parent and less active metabolite, however the net activity of tolterodine is expected to be the same. The pharmacokinetic disposition of tolterodine can be significantly altered in patients with hepatic dysfunction. Therapy with tolterodine should be administered cautiously in patients with severe hepatic impairment and dosage should be reduced to no greater than 1 mg twice daily.

References

  1. "Product Information. Detrol (tolterodine)." Pharmacia and Upjohn, Kalamazoo, MI.
Moderate

Tolterodine (applies to tolterodine) myasthenia gravis

Moderate Potential Hazard, Moderate plausibility.

Tolterodine acts as a competitive antagonist of acetylcholine at postganglionic muscarinic receptors. Caution is recommended when using this agent in patients with myasthenia gravis, a disease characterized by decreased cholinergic activity at the neuromuscular junction.

Moderate

Tolterodine (applies to tolterodine) QT prolongation

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Long QT Syndrome

Tolterodine has been associated with QT prolongation. The effect on QT interval correlates with plasma concentration of tolterodine. Caution is recommended when prescribing this agent to patients with a known history of QT prolongation or to patients who are taking Class IA (e.g., quinidine, procainamide) or Class III (e.g., amiodarone, sotalol) antiarrhythmic medications.

Moderate

Tolterodine (applies to tolterodine) renal dysfunction

Moderate Potential Hazard, Low plausibility.

The renal elimination of tolterodine and active metabolite is limited and a prolonged half-life is not anticipated in patients with renal impairment. However, the pharmacokinetic disposition of tolterodine has not been evaluated in patients with renal impairment and it is recommended that tolterodine be administered cautiously in patients with compromised renal function.

References

  1. "Product Information. Detrol (tolterodine)." Pharmacia and Upjohn, Kalamazoo, MI.

Tolterodine drug interactions

There are 322 drug interactions with tolterodine

Tolterodine alcohol/food interactions

There is 1 alcohol/food interaction with tolterodine

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.