Sorbitol Disease Interactions
There are 5 disease interactions with sorbitol.
Laxatives (applies to sorbitol) inflammatory bowel disease
Major Potential Hazard, Moderate plausibility.
The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.
Laxatives (applies to sorbitol) intestinal obstruction disorders
Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Obstruction
The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.
Sorbitol irrigation (applies to sorbitol) fluid expansion
Major Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction, Congestive Heart Failure
The use of sorbitol solution for urologic irrigation is contraindicated in patients with anuria. In addition, sorbitol irrigation should be administered cautiously in patients with cardiopulmonary or renal dysfunction. Irrigating fluids may enter the systemic circulation, and absorption of large quantities of fluids containing sorbitol may significantly alter cardiopulmonary and renal dynamics. Before and during the urologic procedure, cardiovascular and renal status should be monitored, particularly if the volume absorbed is expected to produce a substantial expansion of the intravascular fluid (e.g., via opened prostatic veins in transurethral prostatectomies).
Sorbitol (applies to sorbitol) diabetes
Moderate Potential Hazard, High plausibility. Applicable conditions: Diabetes Mellitus
Sorbitol is converted to glucose in the body. The use of sorbitol is not recommended as an alternative sweetener in patients with diabetes. Sorbitol is one of the end products of glucose metabolism that results in some of the late complications of diabetes.
Sorbitol (applies to sorbitol) sodium imbalances
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Hypernatremia, Hyponatremia, Dehydration
Shift of sodium-free intracellular fluid into the extracellular compartment following systemic absorption of sorbitol irrigation may lower serum sodium concentration and aggravate preexisting-existing hyponatremia. Excessive loss of water and electrolytes may may also cause hypernatremia. Sustained diuresis from transurethral irrigation with sorbitol irrigation may obscure and intensify inadequate hydration or hypovolemia. Patients with sodium imbalances or dehydration should be closely monitored.
Sorbitol drug interactions
There are 2 drug interactions with sorbitol.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
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