Uptravi Disease Interactions
There are 2 disease interactions with Uptravi (selexipag).
Selexipag (applies to Uptravi) liver impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Liver impairment can increase exposure to selexipag and its metabolites. No dose adjustment is necessary in patients with mild impairment, but a once a day regimen is recommended in patients with moderate hepatic impairment. There is no experience with selexipag in patients with severe hepatic impairment and its use should be avoided in these patients.
Selexipag (applies to Uptravi) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
No adjustment to the dosing regimen of selexipag is required in patients with estimated glomerular filtration rate > 15 mL/min/1.73m2. There is no clinical experience with selexipag in patients with glomerular filtration rates lower than this, or in patients undergoing dialysis.
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Uptravi drug interactions
There are 240 drug interactions with Uptravi (selexipag).
Uptravi alcohol/food interactions
There is 1 alcohol/food interaction with Uptravi (selexipag).
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- Drug class: agents for pulmonary hypertension
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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