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Uptravi Disease Interactions

There are 2 disease interactions with Uptravi (selexipag).

Moderate

Selexipag (applies to Uptravi) liver impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Liver impairment can increase exposure to selexipag and its metabolites. No dose adjustment is necessary in patients with mild impairment, but a once a day regimen is recommended in patients with moderate hepatic impairment. There is no experience with selexipag in patients with severe hepatic impairment and its use should be avoided in these patients.

References

  1. "Product Information. Uptravi (selexipag)." Actelion Pharmaceuticals US Inc (2016):
Moderate

Selexipag (applies to Uptravi) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

No adjustment to the dosing regimen of selexipag is required in patients with estimated glomerular filtration rate > 15 mL/min/1.73m2. There is no clinical experience with selexipag in patients with glomerular filtration rates lower than this, or in patients undergoing dialysis.

References

  1. "Product Information. Uptravi (selexipag)." Actelion Pharmaceuticals US Inc (2016):

Uptravi drug interactions

There are 230 drug interactions with Uptravi (selexipag).

Uptravi alcohol/food interactions

There is 1 alcohol/food interaction with Uptravi (selexipag).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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