Azilect (rasagiline) Disease Interactions
There are 5 disease interactions with Azilect (rasagiline):
Dopamine agonists (Includes Azilect) ↔ hypotension
Severe Potential Hazard, Moderate plausibility. Applies to: Hypotension
Dopamine agonists may impair the systemic regulation of blood pressure, with resultant orthostatic hypotension, especially during dose escalation. Therapy with dopamine agonists should be monitored carefully in patients with Parkinson's disease since they may have an impaired ability to respond to an orthostatic challenge, and also in patients receiving antihypertensive drugs.
- "Product Information. Dostinex (cabergoline)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Sinemet CR (carbidopa-levodopa)." Dupont Pharmaceuticals, Wilmington, DE.
- "Product Information. Mirapex (pramipexole)." Boehringer Ingelheim, Ridgefield, CT.
- Iwasaki S, Hamaguchi K, Iwasaki A, Takakusagi M, Narabayashi Y "Hypotensive effect of long-term levodopa in patients with Parkinson's disease." Eur Neurol 30 (1990): 194-9
- "Product Information. Sinemet (carbidopa-levodopa)." DuPont Pharmaceuticals, Wilmington, DE.
- Hoehn MM "Levodopa-induced postural hypotension. Treatment with fludrocortisone." Arch Neurol 32 (1975): 50-1
Dopaminergic antiparkinson agents (Includes Azilect) ↔ psychosis
Severe Potential Hazard, Moderate plausibility. Applies to: Psychosis
Ordinarily, patients with major psychotic disorder should not be treated with dopaminergic antiparkinson agents, because of the risk of exacerbating psychosis. Hallucinations and psychotic-like behavior have been reported with dopaminergic medications. In addition, certain medications used to treat psychosis may exacerbate the symptoms of Parkinson's disease and may decrease the effectiveness of these drugs.
Rasagiline (Includes Azilect) ↔ hepatic impairment
Severe Potential Hazard, Moderate plausibility. Applies to: Liver Disease
Rasagiline should not be used in patients with moderate to severe hepatic impairment. Patients with mild hepatic impairment should not exceed a dose of 0.5 mg daily.
Rasagiline (Includes Azilect) ↔ hypertension
Moderate Potential Hazard, Moderate plausibility. Applies to: Hypertension
Exacerbation of hypertension may occur during treatment with rasagiline. Dosage adjustment may be necessary if the elevation is sustained. Patients should be monitored for new onset hypertension or hypertension that is not well controlled after starting treatment.
Rasagiline (Includes Azilect) ↔ renal impairment
Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction
Dose adjustment of rasagiline is not required for patients with mild or moderate renal impairment. However, rasagiline has not been studied in patients with severe renal impairment. Caution is advised if used.
Azilect (rasagiline) drug interactions
There are 996 drug interactions with Azilect (rasagiline)
Azilect (rasagiline) alcohol/food interactions
There are 3 alcohol/food interactions with Azilect (rasagiline)
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- Drug class: dopaminergic antiparkinsonism agents
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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