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Propoven (propofol) Disease Interactions

There are 5 disease interactions with Propoven (propofol):


Propofol (Includes Propoven) ↔ Cardiovascular Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Cerebral Vascular Disorder, Hypotension, Heart Block, Ischemic Heart Disease

Propofol can induce severe hypotension and/or cardiovascular depression, particularly during the induction phase of sedation or anesthesia. Therapy with propofol should be administered cautiously in patients with cardiovascular disorders including hemodynamic impairment, increased intracranial pressure, or impaired cerebral circulation.


  1. Mackay P "Fatal cardiovascular collapse following propofol induction in high-risk patients." Anaesth Intensive Care 24 (1996): 125-6
  2. Deutschman CS, Harris AP, Fleisher LA "Changes in heart rate variability under propofol anesthesia: a possible explanation for propofol-induced bradycardia." Anesth Analg 79 (1994): 373-7
  3. Warden JC, Pickford DR "Fatal cardiovascular collapse following propofol induction in high-risk patients and dilemmas in the selection of a short-acting induction agent." Anaesth Intensive Care 23 (1995): 485-7
  4. "Product Information. Diprivan (propofol)." Zeneca Pharmaceuticals, Wilmington, DE.
View all 4 references

Propofol (Includes Propoven) ↔ Hyperlipidemia

Moderate Potential Hazard, High plausibility

Applies to: Hyperlipidemia

Propofol is formulated in an oil-and-water emulsion and elevated triglycerides can occur during extended therapy. Propofol should be administered cautiously in patients with lipid disorders such as primary hyperlipoproteinemia, diabetic hyperlipemia, and pancreatitis. Each milliliter of propofol contains 0.1g of fat (1.1 kcal).


  1. "Product Information. Diprivan (propofol)." Zeneca Pharmaceuticals, Wilmington, DE.
  2. Mateu J, Barrachina F "Hypertriglyceridaemia associated with propofol sedation in critically ill patients." Intensive Care Med 22 (1996): 834-5

Propofol (Includes Propoven) ↔ Renal Dysfunction

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

At high doses (2-3 grams per day), EDTA has been reported, on rare occasions, to be toxic to the renal tubules. Studies to-date, in patients with normal or impaired renal function have not shown any alteration in renal function with propofol Injectable Emulsion containing 0.005% disodium edetate. In patients at risk for renal impairment, urinalysis and urine sediment should be checked before initiation of sedation and then be monitored on alternate days during sedation.


Propofol (Includes Propoven) ↔ Seizure

Moderate Potential Hazard, Moderate plausibility

Applies to: Seizures

Patients with seizure disorders are at increased risk of seizure activity during the recovery phase of sedation or anesthesia following administration of propofol. Clinical monitoring of seizure activity is recommended in patients with or predisposed to seizure disorders.


  1. Samra SK, Sneyd JR, Ross DA, Henry TR "Effects of propofol sedation on seizures and intracranially recorded epileptiform activity in patients with partial epilepsy." Anesthesiology 82 (1995): 843-51
  2. Sutherland MJ, Burt P "Propofol and seizures." Anaesth Intensive Care 22 (1994): 733-7
  3. "Product Information. Diprivan (propofol)." Zeneca Pharmaceuticals, Wilmington, DE.
  4. Cochran D, Price W, Gwinnutt CL "Unilateral convulsion after induction of anaesthesia with propofol." Br J Anaesth 76 (1996): 570-2
  5. Harrigan PWJ, Browne SM, Quail AW "Multiple seizures following re-exposure to propofol." Anaesth Intensive Care 24 (1996): 261-4
  6. DeFriez CB, Wong HC "Seizures and opisthotonos after propofol anesthesia." Anesth Analg 75 (1992): 630-2
View all 6 references

Propofol (Includes Propoven) ↔ Zinc Deficiency

Moderate Potential Hazard, Moderate plausibility

Applies to: Zinc Deficiency, Diarrhea, Sepsis, Burns - External

Reports of mean urinary zinc loss during propofol therapy was approximately 2.5 to 3.0 mg/day in adult patients and 1.5 to 2.0 mg/day in pediatric patients. Practitioners should consider the administration of supplemental zinc during prolonged therapy with propofol in patients who are predisposed to zinc deficiency, such as those with burns, diarrhea, and/or major sepsis. Monitoring is recommended in these patients.

Propoven (propofol) drug Interactions

There are 267 drug interactions with Propoven (propofol)

Propoven (propofol) alcohol/food Interactions

There are 2 alcohol/food interactions with Propoven (propofol)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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