Vivitrol Disease Interactions
There are 2 disease interactions with Vivitrol (naltrexone).
Naltrexone (applies to Vivitrol) hepatic dysfunction
Major Potential Hazard, High plausibility. Applicable conditions: Liver Disease
The use of naltrexone is contraindicated in patients with active hepatitis or hepatic failure. Naltrexone has caused direct hepatocellular injury when administered at doses less than or equal to 5 times the recommended once daily 50 mg dose. Therapy with naltrexone should be administered cautiously in patients with active hepatic disease. Clinical monitoring of transaminase levels prior to and during naltrexone therapy is recommended.
Opiate antagonists (applies to Vivitrol) hepatic/renal dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Opiate antagonists are metabolized by the liver (naltrexone to an active metabolite) and eliminated by the kidney. Hepatic and renal impairment may reduce the metabolism and clearance of opiate antagonists. Dosage adjustment for single dose administration is not necessary, however, repeated doses in patients with hepatic and/or renal dysfunction may require adjustment.
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Vivitrol drug interactions
There are 352 drug interactions with Vivitrol (naltrexone).
Vivitrol alcohol/food interactions
There is 1 alcohol/food interaction with Vivitrol (naltrexone).
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- Drug class: drugs used in alcohol dependence
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.