Mixed grass pollens allergen extract Disease Interactions

The use of allergen immunotherapy, such as mixed grass pollens, ragweed pollen, house dust mite allergen extract, and timothy grass pollen allergen extracts may cause severe allergic reactions such as anaphylaxis and laryngopharyngeal edema. These agents are contraindicated in patients with severe, unstable or uncontrolled asthma, a history of any severe systemic allergic reaction, and a history of any severe local reaction to sublingual allergen immunotherapy as these conditions could compromise breathing and be life-threatening.

The use of allergen immunotherapy, such as mixed grass pollens, ragweed pollen, house dust mite allergen extract, and timothy grass pollen allergen extracts, is contraindicated in patients with a history of eosinophilic esophagitis. This condition could compromise swallowing, lead to food impaction, vomiting, and heartburn which may cause permanent damage to the esophagus.

The use of allergen immunotherapy, such as mixed grass pollens, ragweed pollen, house dust mite allergen extract, and timothy grass pollen allergen extracts may not be suitable for patients with certain medical conditions that may reduce the ability to survive a serious allergic reaction or increase the risk of adverse reactions after epinephrine administration. Examples of these medical conditions include but are not limited to markedly compromised lung function (either chronic or acute), unstable angina, recent myocardial infarction, significant arrhythmia, and uncontrolled hypertension. It is recommended to exercise care in these patients.

The product Oralair, of mixed grass pollens allergen extract, contains lactose monohydrate as one of the inactive ingredients in its formulation. Care should be exercised when using this agent in patients with rare hereditary problems of galactose intolerance, severe lactase deficiency with a severe degree of intolerance to lactose-containing products, or of glucose-galactose malabsorption.