Kynamro (mipomersen) Disease Interactions
There are 2 disease interactions with Kynamro (mipomersen):
Mipomersen (applies to Kynamro) hepatic impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Mipomersen is contraindicated in patients with moderate or severe hepatic impairment (Child-Pugh B or C) or active liver disease, including unexplained persistent elevations of serum transaminases. This agent can cause elevations in transaminases and hepatic steatosis, and could induce steatohepatitis, which could progress to cirrhosis. It is recommended to measure a full liver panel to include ALT, AST, total bilirubin, and alkaline phosphatase before initiation of treatment. If transaminase elevations are accompanied by clinical symptoms of liver injury (e.g., nausea, vomiting, abdominal pain, fever, jaundice, lethargy, flu-like symptoms), increases in bilirubin >= 2 times ULN, or active liver disease, discontinue treatment and identify the probable cause.
Mipomersen (applies to Kynamro) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
The use of mipomersen is not recommended in patients with severe renal impairment, clinically significant proteinuria or on renal dialysis. The safety and efficacy of this agent has not been established in patients with renal impairment or undergoing renal dialysis. Care should be exercised when using this agent in patients with renal dysfunction.
Kynamro (mipomersen) drug interactions
There are 284 drug interactions with Kynamro (mipomersen)
Kynamro (mipomersen) alcohol/food interactions
There is 1 alcohol/food interaction with Kynamro (mipomersen)
More about Kynamro (mipomersen)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- En Español
- 1 Review
- Drug class: miscellaneous antihyperlipidemic agents
- FDA Approval History
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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