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Kynamro Side Effects

Generic Name: mipomersen

Note: This document contains side effect information about mipomersen. Some of the dosage forms listed on this page may not apply to the brand name Kynamro.

For the Consumer

Applies to mipomersen: subcutaneous solution

Along with its needed effects, mipomersen (the active ingredient contained in Kynamro) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking mipomersen:

More Common

  • Chills
  • cough
  • dark urine
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • light-colored stools
  • loss of appetite
  • muscle aches and pains
  • nausea and vomiting
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • vomiting
  • yellow eyes and skin

Less Common

  • Arm, back, or jaw pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • chest pain or discomfort
  • chest tightness or heaviness
  • fast or irregular heartbeat
  • irregular, pounding, or racing heartbeat or pulse
  • rapid weight gain
  • shortness of breath
  • sweating
  • tingling of the hands or feet
  • unusual weight gain or loss

Some side effects of mipomersen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • pain in the arms or legs

Less Common

  • Abdominal or stomach pain

For Healthcare Professionals

Applies to mipomersen: subcutaneous solution

Cardiovascular

Common (1% to 10%): Hypertension (7%), angina pectoris (4%), palpitations (3%)[Ref]

Dermatologic

Very common (10% or more): [All injection site reactions (84%)], erythema (59%), pain (56%), hematoma (32%), pruritus (29%), swelling (18%), discoloration (17%)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (14%)

Common (1% to 10%): Vomiting (4%), abdominal pain (3%)[Ref]

Hepatic

Very common (10% or more): Alanine aminotransferase (ALT) increased (10%)

Common (1% to 10%): Hepatic steatosis (7%), aspartate aminotransferase (AST) increased (6%), liver function test abnormal (5%), hepatic enzyme increased (3%)[Ref]

Immunologic

Rare (less than 0.1%): One case of hypersensitivity with angioedema was reported[Ref]

Metabolic

Common (1% to 10%): Proteinuria (9%), peripheral edema (5%)[Ref]

Musculoskeletal

Common (1% to 10%): Pain in extremity (7%), musculoskeletal pain (4%)[Ref]

Nervous system

Very common (10% or more): Fatigue (15%), headache (12%)

Common (1% to 10%): Pyrexia (8%), chills (6%)[Ref]

Oncologic

Common (1% to 10%): Neoplasms [benign and malignant] (4%)[Ref]

Psychiatric

Common (1% to 10%): Insomnia (3%)[Ref]

Renal

Rare (less than 0.1%): One case of glomerular nephritis was reported[Ref]

References

1. "Product Information. Kynamro (mipomersen)." Genzyme Corporation, Cambridge, MA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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