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Vecamyl (mecamylamine) Disease Interactions

There are 7 disease interactions with Vecamyl (mecamylamine):

Major

Mecamylamine (Includes Vecamyl) ↔ Cardiovascular Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Ischemic Heart Disease, Myocardial Infarction

The use of mecamylamine is contraindicated in patients with coronary artery disease or insufficiency or a recent myocardial infarction. Mecamylamine blocks sympathetic ganglia causing vasodilation, increased peripheral blood flow, and decreased blood pressure.

References

  1. "Product Information. Inversine (mecamylamine)." Merc & Co Inc, West Point, PA.
Major

Mecamylamine (Includes Vecamyl) ↔ Cerebrovascular Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Cerebral Vascular Disorder

Cerebrovascular ischemia can occur as a result of marked hypotension during mecamylamine therapy. Therapy with mecamylamine should be administered cautiously in patients with or a history of cerebrovascular disorders.

References

  1. "Product Information. Inversine (mecamylamine)." Merc & Co Inc, West Point, PA.
Major

Mecamylamine (Includes Vecamyl) ↔ Glaucoma

Severe Potential Hazard, Moderate plausibility

Applies to: Glaucoma/Intraocular Hypertension

The use of mecamylamine is contraindicated in patients with glaucoma.

Major

Mecamylamine (Includes Vecamyl) ↔ Neurologic Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Myoneural Disorder, Psychosis

CNS toxicity such as tremors, choreiform movements, altered mental status, and convulsions have occurred rarely. Patients with cerebral or renal impairment are at increased risk for mecamylamine- associated CNS toxicity. Therapy with mecamylamine should be administered cautiously in patients with or predisposition to neurological disorders. Clinical monitoring of neurological status and renal function (as indicated) is recommended.

References

  1. "Product Information. Inversine (mecamylamine)." Merc & Co Inc, West Point, PA.
Major

Mecamylamine (Includes Vecamyl) ↔ Renal Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Mecamylamine is primarily eliminated by the kidney, and it should be given with great discretion, if at all, when renal insufficiency is manifested by a rising or elevated BUN. This drug is contraindicated in uremia.

References

  1. "Product Information. Inversine (mecamylamine)." Merc & Co Inc, West Point, PA.
Major

Mecamylamine (Includes Vecamyl) ↔ Urinary Retention

Severe Potential Hazard, High plausibility

Applies to: Urinary Retention

The parasympathetic blocking activity of mecamylamine can cause bladder atony and urinary retention. Therapy with mecamylamine should be administered cautiously in patients with urinary retention, prostatic hypertrophy, bladder neck obstruction, or urethral stricture.

Moderate

Mecamylamine (Includes Vecamyl) ↔ Dehydration

Moderate Potential Hazard, Moderate plausibility

Applies to: Fever, Dehydration, Diarrhea, Vomiting, Bleeding

The action of mecamylamine may be potentiated by excessive heat, fever, infection, bleeding, vigorous exercise and salt depletion, as a result of diminished intake or increase excretion due to diarrhea, vomiting, excessive sweating or diuretics.

Vecamyl (mecamylamine) drug Interactions

There are 391 drug interactions with Vecamyl (mecamylamine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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