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Magnesium chloride Disease Interactions

There are 2 disease interactions with magnesium chloride.


Magnesium IV (applies to magnesium chloride) cardiac disease

Major Potential Hazard, High plausibility. Applicable conditions: Heart Block, Myocardial Infarction

The parenteral administration of magnesium is contraindicated in patients with heart block or heart damage from myocardial infarction. These conditions may be exacerbated during magnesium infusion. High serum levels of magnesium (> 4.5 mEq/L) can cause sinus bradycardia, AV block, nodal rhythms, and bundle branch block, which can progress to asystole and cardiac arrest at magnesium levels of approximately 14 mEq/L to 15 mEq/L. If parenteral magnesium is used in patients with preexisting conduction disturbances, it should be infused at a slower rate, and cardiac function and serum magnesium level should be closely monitored. The usual precautionary measures should be observed to prevent hypermagnesemia, and IV calcium salts (e.g., calcium gluconate), pressors, cardiac pacemakers, and equipment for supportive care should be immediately available in case of acute magnesium intoxication.


  1. Sherer DM, Cialone PR, Abramowicz JS, Woods JR Jr "Transient symptomatic subendocardial ischemia during intravenous magnesium sulfate tocolytic therapy." Am J Obstet Gynecol 166 (1992): 33-5
  2. Viskin S, Belhassen B, Laniado S "Deterioration of ventricular tachycardia to ventricular fibrillation after rapid intravenous administration of magnesium sulfate." Chest 101 (1992): 1445-7
  3. "Product Information. Magnesium Sulfate (magnesium sulfate)." Abbott Pharmaceutical (2001):

Magnesium salts (applies to magnesium chloride) renal dysfunction

Major Potential Hazard, High plausibility.

Magnesium is eliminated by the kidney. The serum concentration of magnesium is increased in patients with renal impairment. Magnesium toxicity includes CNS depression, muscular paralysis, respiratory depression, hypotension and prolonged cardiac conduction time. Disappearance of the patellar reflex is a useful clinical sign of magnesium intoxication. Therapy with magnesium should be administered cautiously and dosages should be modified in patients with compromised renal function. Clinical monitoring of serum magnesium levels is recommended.


  1. "Product Information. Mag-Ox 400 (magnesium oxide)." Blaine Company Inc. (2001):
  2. "Product Information. Uro-Mag (magnesium oxide)." Blaine Company Inc. (2001):
  3. "Product Information. Slow-Mag (magnesium chloride)." Searle (2001):
  4. "Product Information. Magonate (magnesium gluconate)." Fleming and Company (2001):
  5. "Product Information. Losospan (magaldrate)." Whitehall-Robbins (2001):
View all 5 references

Magnesium chloride drug interactions

There are 64 drug interactions with magnesium chloride.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.