Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief (loratadine) Disease Interactions
There is 1 disease interaction with Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief (loratadine):
Loratadine (Includes Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief) ↔ Renal/Liver Disease
Moderate Potential Hazard, High plausibility
Applies to: Renal Dysfunction, Liver Disease
Loratadine is primarily converted by the liver to an active metabolite, and both parent drug and metabolite are excreted in the urine. Patients with renal and/or liver disease may be at greater risk for adverse effects from loratadine due to drug and metabolite accumulation. The manufacturer recommends one-half the regular dosage initially in patients with liver failure or decreased renal function (GFR < 30 mL/min). Due to the differential effects of hepatic impairment on the serum half-life and clearance of loratadine and pseudoephedrine, the use of products containing a fixed combination of these drugs is not recommended in the presence of liver failure.
- Monroe EW "Safety and efficacy of loratadine in urticaria." Int J Dermatol 35 (1996): 837-41
- Matzke GR, Halstenson CE, Opsahl JA, Hilbert J, Perentesis G, Radwanski E, Zampaglione N "Pharmacokinetics of loratadine in patients with renal insufficiency." J Clin Pharmacol 30 (1990): 364-71
- Clissold SP, Sorkin EM, Goa KL "Loratadine. A preliminary review of its pharmacodynamic properties and therapeutic efficacy." Drugs 37 (1989): 42-57
Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief (loratadine) drug Interactions
There are 76 drug interactions with Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief (loratadine)
Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief (loratadine) alcohol/food Interactions
There is 1 alcohol/food interaction with Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief (loratadine)
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2017 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.