Dimetapp Children's ND Non-Drowsy Allergy (loratadine) Disease Interactions
There is 1 disease interaction with Dimetapp Children's ND Non-Drowsy Allergy (loratadine):
Loratadine (Includes Dimetapp Children's ND Non-Drowsy Allergy) ↔ Renal/Liver Disease
Moderate Potential Hazard, High plausibility
Applies to: Renal Dysfunction, Liver Disease
Loratadine is primarily converted by the liver to an active metabolite, and both parent drug and metabolite are excreted in the urine. Patients with renal and/or liver disease may be at greater risk for adverse effects from loratadine due to drug and metabolite accumulation. The manufacturer recommends one-half the regular dosage initially in patients with liver failure or decreased renal function (GFR < 30 mL/min). Due to the differential effects of hepatic impairment on the serum half-life and clearance of loratadine and pseudoephedrine, the use of products containing a fixed combination of these drugs is not recommended in the presence of liver failure.
- Monroe EW "Safety and efficacy of loratadine in urticaria." Int J Dermatol 35 (1996): 837-41
- Matzke GR, Halstenson CE, Opsahl JA, Hilbert J, Perentesis G, Radwanski E, Zampaglione N "Pharmacokinetics of loratadine in patients with renal insufficiency." J Clin Pharmacol 30 (1990): 364-71
- Clissold SP, Sorkin EM, Goa KL "Loratadine. A preliminary review of its pharmacodynamic properties and therapeutic efficacy." Drugs 37 (1989): 42-57
- Hilbert J, Moritzen V, Parks A, Radwanski E, Perentesis G, Symchowicz S, Zampaglione N "The pharmacokinetics of loratadine in normal geriatric volunteers." J Int Med Res 16 (1988): 50-60
- "Product Information. Claritin (loratadine)." Schering Laboratories, Kenilworth, NJ.
- Schiano TD, Bellary SV, Cassidy MJ, Thomas RM, Black M "Subfulminant liver failure and severe hepatotoxicity caused by loratadine use." Ann Intern Med 125 (1996): 738-40
Dimetapp Children's ND Non-Drowsy Allergy (loratadine) drug Interactions
There are 77 drug interactions with Dimetapp Children's ND Non-Drowsy Allergy (loratadine)
Dimetapp Children's ND Non-Drowsy Allergy (loratadine) alcohol/food Interactions
There is 1 alcohol/food interaction with Dimetapp Children's ND Non-Drowsy Allergy (loratadine)
Drug Interaction Classification
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.