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Allergy Relief 24 Hour (loratadine) Disease Interactions

There is 1 disease interaction with Allergy Relief 24 Hour (loratadine):

Moderate

Loratadine (Includes Allergy Relief 24 Hour) ↔ Renal/Liver Disease

Moderate Potential Hazard, High plausibility

Applies to: Renal Dysfunction, Liver Disease

Loratadine is primarily converted by the liver to an active metabolite, and both parent drug and metabolite are excreted in the urine. Patients with renal and/or liver disease may be at greater risk for adverse effects from loratadine due to drug and metabolite accumulation. The manufacturer recommends one-half the regular dosage initially in patients with liver failure or decreased renal function (GFR < 30 mL/min). Due to the differential effects of hepatic impairment on the serum half-life and clearance of loratadine and pseudoephedrine, the use of products containing a fixed combination of these drugs is not recommended in the presence of liver failure.

References

  1. Monroe EW "Safety and efficacy of loratadine in urticaria." Int J Dermatol 35 (1996): 837-41
  2. Matzke GR, Halstenson CE, Opsahl JA, Hilbert J, Perentesis G, Radwanski E, Zampaglione N "Pharmacokinetics of loratadine in patients with renal insufficiency." J Clin Pharmacol 30 (1990): 364-71
  3. Clissold SP, Sorkin EM, Goa KL "Loratadine. A preliminary review of its pharmacodynamic properties and therapeutic efficacy." Drugs 37 (1989): 42-57
View all 6 references

Allergy Relief 24 Hour (loratadine) drug Interactions

There are 69 drug interactions with Allergy Relief 24 Hour (loratadine)

Allergy Relief 24 Hour (loratadine) alcohol/food Interactions

There is 1 alcohol/food interaction with Allergy Relief 24 Hour (loratadine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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