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Loncastuximab tesirine Disease Interactions

There are 2 disease interactions with loncastuximab tesirine.

Moderate

Loncastuximab tesirine (applies to loncastuximab tesirine) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Patients with mild hepatic impairment should be monitored for a potential increase of adverse effects when using loncastuximab tesirine. This drug has not been studied in patients with moderate or severe hepatic impairment.

References (1)
  1. (2021) "Product Information. Zynlonta (loncastuximab tesirine)." ADC Therapeutics America
Moderate

Loncastuximab tesirine (applies to loncastuximab tesirine) kidney disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

The effects of severe renal impairment and end-stage renal disease in the pharmacokinetics of loncastuximab tesirine is unknown.

References (1)
  1. (2021) "Product Information. Zynlonta (loncastuximab tesirine)." ADC Therapeutics America

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Loncastuximab tesirine drug interactions

There are 523 drug interactions with loncastuximab tesirine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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