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Ixabepilone Disease Interactions

There are 4 disease interactions with ixabepilone.

Major

Ixabepilone (applies to ixabepilone) cytopenia

Major Potential Hazard, Moderate plausibility. Applicable conditions: Thrombocytopenia, Neutropenia, Immunodeficiency

Ixabepilone is contraindicated in patients who have a neutrophil count <1500 cells/mm3 or a platelet count <100,000 cells/mm3.

References

  1. "Product Information. Ixempra (ixabepilone)." Bristol-Myers Squibb (2007):
Major

Ixabepilone (applies to ixabepilone) liver dysfunction

Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease, Hyperbilirubinemia

The use of ixabepilone in combination with capecitabine is contraindicated in patients with AST or ALT >2.5 x ULN or bilirubin >1 x ULN due to increased risk of toxicity and neutropenia-related death.

References

  1. "Product Information. Ixempra (ixabepilone)." Bristol-Myers Squibb (2007):
Moderate

Ixabepilone (applies to ixabepilone) cardiovascular

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias, Ischemic Heart Disease, Cardiovascular Disease

The use of ixabepilone in combination with capecitabine may increase cardiac adverse reactions, such as myocardial ischemia and ventricular dysfunction. Care should be exercised when using this agent in combination with capecitabine in patients with a history of cardiac disease. It is recommended to discontinue treatment in patients who develop cardiac ischemia or impaired cardiac function.

References

  1. "Product Information. Ixempra (ixabepilone)." Bristol-Myers Squibb (2007):
Moderate

Ixabepilone (applies to ixabepilone) neuropathy

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Diabetes Mellitus, Peripheral Neuropathy

The use of ixabepilone in combination with capecitabine may cause peripheral neuropathy. Patients treated with ixabepilone in combination with capecitabine should be monitored for symptoms of neuropathy. Patients experiencing new or worsening symptoms may require a reduction or delay in the dose. Caution should be used when treating patients with diabetes mellitus or preexisting peripheral neuropathy.

References

  1. "Product Information. Ixempra (ixabepilone)." Bristol-Myers Squibb (2007):

Ixabepilone drug interactions

There are 399 drug interactions with ixabepilone.

Ixabepilone alcohol/food interactions

There is 1 alcohol/food interaction with ixabepilone.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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