Lente Iletin II (insulin zinc) Disease Interactions
There are 3 disease interactions with Lente Iletin II (insulin zinc):
Insulin (Includes Lente Iletin II) ↔ Renal/Liver Disease
Moderate Potential Hazard, Moderate plausibility
Applies to: Liver Disease, Renal Dysfunction
Insulin requirements may be diminished in patients with renal or hepatic impairment due to reduced insulin metabolism and, in the latter case, also to reduced capacity for gluconeogenesis. Lower initial dosages may be appropriate, with careful monitoring of plasma glucose levels and dosing adjustments.
References
- "Product Information. Novolog (insulin aspart)" Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
- "Product Information. Lantus (insulin glargine)" Aventis Pharmaceuticals, Swiftwater, PA.
- "Product Information. Humulin BR (insulin)." Lilly, Eli and Company, Indianapolis, IN.
Insulin- Hypokalemia
Moderate Potential Hazard, Moderate plausibility
Applies to: Hypokalemia
Hypokalemia may commonly occur during treatment with insulin. Use with caution in patients who may be particularly at risk of developing hypokalemia (e.g., patients using potassium-lowering medications, patients taking medications sensitive to serum potassium concentrations).
Insulin/Oral Hypoglycemic Agents (Includes Lente Iletin II) ↔ Hypoglycemia
Moderate Potential Hazard, Moderate plausibility
Applies to: Anorexia/Feeding Problems, Adrenal Insufficiency, Malnourished, Autonomic Neuropathy, Panhypopituitarism
Hypoglycemia may commonly occur during treatment with insulin and/or oral hypoglycemic agents. Care should be taken in patients who may be particularly susceptible to the development of hypoglycemic episodes during the use of these drugs, including those who are debilitated or malnourished, those with defective counterregulatory mechanisms (e.g., autonomic neuropathy and adrenal or pituitary insufficiency), and those receiving beta-adrenergic blocking agents.
References
- "Product Information. Glucotrol (glipizide)." Pfizer US Pharmaceuticals, New York, NY.
- Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998):
- "Product Information. Glucophage (metformin)." Bristol-Myers Squibb, Princeton, NJ.
Lente Iletin II (insulin zinc) drug Interactions
There are 843 drug interactions with Lente Iletin II (insulin zinc)
Lente Iletin II (insulin zinc) alcohol/food Interactions
There is 1 alcohol/food interaction with Lente Iletin II (insulin zinc)
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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