Guanabenz Disease Interactions
There are 5 disease interactions with guanabenz.
Alpha-2 agonists (central) (applies to guanabenz) bradyarrhythmia
Moderate Potential Hazard, High plausibility. Applicable conditions: Heart Block, Sinus Node Dysfunction
Central alpha-2 adrenoreceptor agonists reduce sympathetic outflow from the central nervous system. Heart rate is decreased, which may lead to or exacerbate sinus bradycardia and atrioventricular block. Therapy with central alpha-2 adrenoreceptor agonists should be administered cautiously in patients with conduction disturbances such as sinus node dysfunction or AV nodal disease.
Alpha-2 agonists (central) (applies to guanabenz) depression
Moderate Potential Hazard, Moderate plausibility.
Central alpha-2 adrenoreceptor agonists may occasionally cause mental depression and should be used cautiously in patients with a history of depression.
Alpha-2 agonists (central) (applies to guanabenz) hypotension
Moderate Potential Hazard, High plausibility. Applicable conditions: Cerebrovascular Insufficiency, Ischemic Heart Disease, Peripheral Arterial Disease
Central alpha-2 adrenoreceptor agonists reduce sympathetic outflow from the central nervous system, resulting in decreases in heart rate, peripheral and renovascular resistance, and blood pressure. Therapy with these agents should be administered cautiously in patients with hypotension or conditions that may be exacerbated by decreased blood pressure and perfusion, such as coronary insufficiency, peripheral vascular disease (e.g., Raynaud's syndrome), cerebrovascular disease, or recent myocardial infarction.
Guanabenz (applies to guanabenz) liver disease
Moderate Potential Hazard, High plausibility.
Guanabenz is primarily metabolized by the liver. Pharmacokinetic data indicate that the plasma clearance of guanabenz is significantly reduced and its elimination half-life significantly prolonged in patients with liver disease. Therapy with guanabenz should be administered cautiously in patients with impaired hepatic function. Careful monitoring of blood pressure during dosage titration is recommended.
Guanabenz (applies to guanabenz) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
The disposition of orally administered guanabenz is altered modestly in renal impairment. The manufacturer states that the plasma clearance of guanabenz is reduced and its half-life prolonged in patients with impaired renal function, and more so in those on hemodialysis. The clinical significance of these findings is unknown. Careful monitoring of blood pressure during dosage titration is recommended.
Switch to professional interaction data
Guanabenz drug interactions
There are 186 drug interactions with guanabenz.
Guanabenz alcohol/food interactions
There is 1 alcohol/food interaction with guanabenz.
More about guanabenz
- guanabenz consumer information
- Check interactions
- Compare alternatives
- Reviews (1)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: antiadrenergic agents, centrally acting
- Breastfeeding
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
See also:
Lasix
Lasix is a loop diuretic used to treat fluid retention from heart, liver, or kidney conditions, and ...
Enalapril
Enalapril is used to treat high blood pressure, congestive heart failure and to improve survival ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Valsartan
Valsartan is an angiotensin II receptor blocker (ARB) that may be used to treat high blood pressure ...
Hydrochlorothiazide
HCTZ (hydrochlorothiazide) used to treat high blood pressure (hypertension) and edema. Includes ...
Atenolol
Atenolol is used to treat angina (chest pain) and hypertension (high blood pressure). Learn about ...
Furosemide
Furosemide is a loop diuretic used to treat fluid retention and high blood pressure by increasing ...
Metoprolol
Metoprolol is used to treat angina (chest pain) and hypertension (high blood pressure). Learn about ...
Losartan
Losartan is used to treat high blood pressure (hypertension). It is also used to lower the risk of ...
Lisinopril
Lisinopril is an ACE inhibitor. It is used to treat high blood pressure, congestive heart failure ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.