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Emend for Injection (fosaprepitant) Disease Interactions

There are 2 disease interactions with Emend for Injection (fosaprepitant):

Moderate

Fosaprepitant (Includes Emend for Injection) ↔ Qt Prolongation

Moderate Potential Hazard, Moderate plausibility

Applies to: Long QT Syndrome

Fosaprepitant, a prodrug of aprepitant, is a weak inhibitor of CYP3A4, and aprepitant is a substrate, inhibitor, and inducer of CYP3A4. An increased plasma concentration of fosaprepitant could cause QT prolongation. Caution is advised in patients with long QT, and in patients receiving other drugs that are CYP3A4 substrates as it may result in a risk of higher plasma concentrations and adverse events. Close monitoring is recommended in these patients.

Moderate

Fosaprepitant (Includes Emend for Injection) ↔ Severe Hepatic Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

There are no clinical or pharmacokinetic data in patients with severe hepatic impairment (Child-Pugh greater than 9), therefore caution and monitoring is recommended when using fosaprepitant in these patients.

Emend for Injection (fosaprepitant) drug Interactions

There are 510 drug interactions with Emend for Injection (fosaprepitant)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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