Fenoldopam Disease Interactions

Fenoldopam causes a dose-related fall in blood pressure that may worsen congestive heart failure. Therapy with fenoldopam should be administered cautiously in patients with heart failure. Monitoring blood pressure at regular intervals is recommended.

Fenoldopam causes a dose-dependent increase in intraocular pressure. Therapy with fenoldopam should be administered cautiously in patients with glaucoma or intraocular hypertension. Intraocular pressure may return to baseline in 2 hours following discontinuation of fenoldopam.

The use of fenoldopam is associated with hypokalemia (less than 3 mEq/L after 6 hours of infusion). Therapy with fenoldopam should be administered cautiously in patients with preexisting hypokalemia. Monitoring serum electrolytes and potassium replacement as required is recommended.

Fenoldopam may cause symptomatic hypotension that may exacerbate cerebral infarction or hemorrhage. Monitoring blood pressure closely during administration is recommended.

The use of fenoldopam is associated with producing dose-related compensatory tachycardia, particularly with infusion rates greater than 0.1 mcg/kg/min in adults and >0.8 mcg/kg/min in pediatric patients. Tachycardia may diminish over time, but remains substantial at higher doses. Care should be exercised when using this agent in patients at risk.