Fenoldopam Disease Interactions
There are 5 disease interactions with fenoldopam.
Fenoldopam (applies to fenoldopam) congestive heart failure
Major Potential Hazard, High plausibility.
Fenoldopam causes a dose-related fall in blood pressure that may worsen congestive heart failure. Therapy with fenoldopam should be administered cautiously in patients with heart failure. Monitoring blood pressure at regular intervals is recommended.
References (5)
- Panacek EA, Bednarczyk EM, Dunbar LM, Foulke GE, Holcslaw TL (1995) "Randomized, prospective trial of fenoldopam vs sodium nitroprusside in the treatment of acute severe hypertension. Fenoldopam Study Group." Acad Emerg Med, 2, p. 959-65
- Ventura HO, Messerli FH, Frohlich ED, Kobrin I, Oigman W, Dunn FG, Carey RM (1984) "Immediate hemodynamic effects of a dopamine-receptor agonist (fenoldopam) in patients with essential hypertension." Circulation, 69, p. 1142-5
- Gluck Z, Jossen L, Weidmann P, Gnadinger MP, Peheim E (1987) "Cardiovascular and renal profile of acute peripheral dopamine1- receptor agonism with fenoldopam." Hypertension, 10, p. 43-54
- (2001) "Product Information. Corlopam (fenoldopam)." Neurex
- Brogden RN, Markham A (1997) "Fenoldopam: a review of its pharmacodynamic and pharmacokinetic properties and intravenous clinical potential in the management of hypertensive urgencies and emergencies." Drugs, 54, p. 634-50
Fenoldopam (applies to fenoldopam) glaucoma
Major Potential Hazard, High plausibility. Applicable conditions: Glaucoma/Intraocular Hypertension
Fenoldopam causes a dose-dependent increase in intraocular pressure. Therapy with fenoldopam should be administered cautiously in patients with glaucoma or intraocular hypertension. Intraocular pressure may return to baseline in 2 hours following discontinuation of fenoldopam.
References (3)
- Everitt DE, Boike SC, Piltz-Seymour JR, VanCoevorden R, Audet P, Zariffa N, Jorkasky D (1997) "Effect of intravenous fenoldopam on intraocular pressure in ocular hypertension." J Clin Pharmacol, 37, p. 312-20
- (2001) "Product Information. Corlopam (fenoldopam)." Neurex
- Brogden RN, Markham A (1997) "Fenoldopam: a review of its pharmacodynamic and pharmacokinetic properties and intravenous clinical potential in the management of hypertensive urgencies and emergencies." Drugs, 54, p. 634-50
Fenoldopam (applies to fenoldopam) hypokalemia
Major Potential Hazard, High plausibility.
The use of fenoldopam is associated with hypokalemia (less than 3 mEq/L after 6 hours of infusion). Therapy with fenoldopam should be administered cautiously in patients with preexisting hypokalemia. Monitoring serum electrolytes and potassium replacement as required is recommended.
References (5)
- Panacek EA, Bednarczyk EM, Dunbar LM, Foulke GE, Holcslaw TL (1995) "Randomized, prospective trial of fenoldopam vs sodium nitroprusside in the treatment of acute severe hypertension. Fenoldopam Study Group." Acad Emerg Med, 2, p. 959-65
- Nichols AJ, Ruffolo RR Jr, Brooks DP (1990) "The pharmacology of fenoldopam." Am J Hypertens, 3, s116-9
- Ruilope LM, Robles RG, Miranda B, Tovar J, Alcazar JM, Sancho J, Rodicio JL, Martinez A, Astorga A, Beck T (1988) "Renal effects of fenoldopam in refractory hypertension." J Hypertens, 6, p. 665-9
- Girbes AR, Smit AJ, Meijer S, Reitsma WD (1990) "Renal and endocrine effects of fenoldopam and metoclopramide in normal man." Nephron, 56, p. 179-85
- (2001) "Product Information. Corlopam (fenoldopam)." Neurex
Fenoldopam (applies to fenoldopam) hypotension
Major Potential Hazard, High plausibility. Applicable conditions: Cerebral Vascular Disorder
Fenoldopam may cause symptomatic hypotension that may exacerbate cerebral infarction or hemorrhage. Monitoring blood pressure closely during administration is recommended.
References (7)
- White WB, Radford MJ, Gonzalez FM, Weed SG, McCabe EJ, Katz AM (1988) "Selective dopamine-1 agonist therapy in severe hypertension: effects of intravenous fenoldopam." J Am Coll Cardiol, 11, p. 1118-23
- Panacek EA, Bednarczyk EM, Dunbar LM, Foulke GE, Holcslaw TL (1995) "Randomized, prospective trial of fenoldopam vs sodium nitroprusside in the treatment of acute severe hypertension. Fenoldopam Study Group." Acad Emerg Med, 2, p. 959-65
- Ventura HO, Messerli FH, Frohlich ED, Kobrin I, Oigman W, Dunn FG, Carey RM (1984) "Immediate hemodynamic effects of a dopamine-receptor agonist (fenoldopam) in patients with essential hypertension." Circulation, 69, p. 1142-5
- Munger MA, Rutherford WF, Anderson L, Hakki AI, Gonzalez FM, Bednarczyk EM, Emmanuel G, Weed SG, Panacek EA, Green JA (1990) "Assessment of intravenous fenoldopam mesylate in the management of severe systemic hypertension." Crit Care Med, 18, p. 502-4
- Gluck Z, Jossen L, Weidmann P, Gnadinger MP, Peheim E (1987) "Cardiovascular and renal profile of acute peripheral dopamine1- receptor agonism with fenoldopam." Hypertension, 10, p. 43-54
- (2001) "Product Information. Corlopam (fenoldopam)." Neurex
- Brogden RN, Markham A (1997) "Fenoldopam: a review of its pharmacodynamic and pharmacokinetic properties and intravenous clinical potential in the management of hypertensive urgencies and emergencies." Drugs, 54, p. 634-50
Fenoldopam (applies to fenoldopam) tachycardia
Major Potential Hazard, Moderate plausibility. Applicable conditions: Tachyarrhythmia
The use of fenoldopam is associated with producing dose-related compensatory tachycardia, particularly with infusion rates greater than 0.1 mcg/kg/min in adults and >0.8 mcg/kg/min in pediatric patients. Tachycardia may diminish over time, but remains substantial at higher doses. Care should be exercised when using this agent in patients at risk.
References (6)
- Panacek EA, Bednarczyk EM, Dunbar LM, Foulke GE, Holcslaw TL (1995) "Randomized, prospective trial of fenoldopam vs sodium nitroprusside in the treatment of acute severe hypertension. Fenoldopam Study Group." Acad Emerg Med, 2, p. 959-65
- Ventura HO, Messerli FH, Frohlich ED, Kobrin I, Oigman W, Dunn FG, Carey RM (1984) "Immediate hemodynamic effects of a dopamine-receptor agonist (fenoldopam) in patients with essential hypertension." Circulation, 69, p. 1142-5
- Gluck Z, Jossen L, Weidmann P, Gnadinger MP, Peheim E (1987) "Cardiovascular and renal profile of acute peripheral dopamine1- receptor agonism with fenoldopam." Hypertension, 10, p. 43-54
- Holcslaw TL, Beck TR (1990) "Clinical experience with intravenous fenoldopam." Am J Hypertens, 3, s120-5
- (2001) "Product Information. Corlopam (fenoldopam)." Neurex
- Brogden RN, Markham A (1997) "Fenoldopam: a review of its pharmacodynamic and pharmacokinetic properties and intravenous clinical potential in the management of hypertensive urgencies and emergencies." Drugs, 54, p. 634-50
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Fenoldopam drug interactions
There are 268 drug interactions with fenoldopam.
Fenoldopam alcohol/food interactions
There is 1 alcohol/food interaction with fenoldopam.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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