Dexmedetomidine Disease Interactions
There are 4 disease interactions with dexmedetomidine.
Anxiolytics/sedatives/hypnotics (applies to dexmedetomidine) depression
Major Potential Hazard, Moderate plausibility.
A variety of abnormal thinking and behavior changes have been reported to occur in association with the use of most anxiolytics, sedatives and hypnotics. Some of these changes include decreased inhibition, aggressiveness, agitation, and hallucinations. These drugs can cause or exacerbate mental depression and cause suicidal behavior and ideation. Therapy with these drugs should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. It may be prudent to refrain from dispensing large quantities of medication to these patients.
References
- "Product Information. Buspar (buspirone)." Bristol-Myers Squibb (2002):
- "Product Information. Ambien (zolpidem)." sanofi-aventis (2001):
- "Product Information. Placidyl (ethchlorvynol)." Abbott Pharmaceutical (2001):
- "Product Information. Aquachloral Supprettes (chloral hydrate)." Medisca Inc (2001):
- "Product Information. Equanil (meprobamate)." Wallace Laboratories (2001):
- "Product Information. Sonata (zaleplon)." Wyeth-Ayerst Laboratories (2001):
- "Product Information. Precedex (dexmedetomidine)." Abbott Pharmaceutical (2001):
- "Product Information. Xyrem (sodium oxybate)." Orphan Medical (2002):
- "Product Information. Lunesta (eszopiclone)." Sepracor Inc (2004):
- "Product Information. Rozerem (ramelteon)." Takeda Pharmaceuticals America (2005):
- "Product Information. Silenor (doxepin)." Somaxon Pharmaceuticals (2010):
- "Product Information. Unisom (doxylamine)." Pfizer U.S. Pharmaceuticals Group (2013):
- "Product Information. Hetlioz (tasimelteon)." Vanda Pharmaceuticals Inc (2014):
- "Product Information. Belsomra (suvorexant)." Merck & Co., Inc (2014):
Anxiolytics/sedatives/hypnotics (applies to dexmedetomidine) glaucoma
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Glaucoma/Intraocular Hypertension, Urinary Retention
Some hypnotic drugs can have an anticholinergic effect and should be used with caution in patients with glaucoma, and trouble urinating due to retention or enlarged prostate.
References
- "Product Information. Benadryl (diphenhydramine)." Parke-Davis (2002):
- "Product Information. Unisom (doxylamine)." Pfizer U.S. Pharmaceuticals Group (2013):
Anxiolytics/sedatives/hypnotics (applies to dexmedetomidine) liver disease
Moderate Potential Hazard, Moderate plausibility.
In general, anxiolytics, sedatives and hypnotics are extensively metabolized by the liver. Their plasma clearance may be decreased and their half-life prolonged in patients with impaired hepatic function. Therapy with these drugs should be administered cautiously in patients with liver disease (some are not recommended in severe liver impairment), and the dosage should be adjusted accordingly. Laboratory testing is recommended prior and during treatment.
References
- "Product Information. Buspar (buspirone)." Bristol-Myers Squibb (2002):
- "Product Information. Placidyl (ethchlorvynol)." Abbott Pharmaceutical (2001):
- "Product Information. Aquachloral Supprettes (chloral hydrate)." Medisca Inc (2001):
- "Product Information. Equanil (meprobamate)." Wallace Laboratories (2001):
- "Product Information. Sonata (zaleplon)." Wyeth-Ayerst Laboratories (2001):
- "Product Information. Precedex (dexmedetomidine)." Abbott Pharmaceutical (2001):
- "Product Information. Xyrem (sodium oxybate)." Orphan Medical (2002):
- "Product Information. Lunesta (eszopiclone)." Sepracor Inc (2004):
- "Product Information. Rozerem (ramelteon)." Takeda Pharmaceuticals America (2005):
- "Product Information. Silenor (doxepin)." Somaxon Pharmaceuticals (2010):
- "Product Information. Intermezzo (zolpidem)." Purdue Pharma LP (2011):
- "Product Information. Hetlioz (tasimelteon)." Vanda Pharmaceuticals Inc (2014):
- "Product Information. Belsomra (suvorexant)." Merck & Co., Inc (2014):
Dexmedetomidine (applies to dexmedetomidine) cardiovascular dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Cardiovascular Disease, Heart Block, Diabetes Mellitus
The use of dexmedetomidine injection infusion decreases sympathetic nervous system activity and can cause hypotension, significant bradycardia and sinus arrest. Caution should be exercised when administered to patients with advanced heart block, severe ventricular dysfunction or any significant cardiovascular dysfunction. Hypotension or bradycardia can be expected to be more pronounced in patients with hypovolemia, diabetes mellitus, chronic hypertension and in the elderly.
References
- "Product Information. Precedex (dexmedetomidine)." Abbott Pharmaceutical (2001):
Dexmedetomidine drug interactions
There are 349 drug interactions with dexmedetomidine.
Dexmedetomidine alcohol/food interactions
There is 1 alcohol/food interaction with dexmedetomidine.
More about dexmedetomidine
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- During pregnancy
- Drug class: miscellaneous anxiolytics, sedatives and hypnotics
- Breastfeeding
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.