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Children's Zyrtec Disease Interactions

There are 2 disease interactions with Children's Zyrtec (cetirizine).


Cetirizine (applies to Children's Zyrtec) alcohol

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Acute Alcohol Intoxication

Alcohol should be avoided when using cetirizine, and some other antihistamines. Cetirizine may produce drowsiness that may be increase by the use of alcohol, sedatives and tranquilizers.


  1. (2001) "Product Information. Zyrtec (cetirizine)." Pfizer U.S. Pharmaceuticals

Cetirizine (applies to Children's Zyrtec) renal/liver disease

Moderate Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction

Cetirizine is eliminated primarily by the kidney but also undergoes metabolism in the liver to some extent. Patients with renal and/or liver disease may be at greater risk for adverse effects from cetirizine due to decreased drug clearance. The manufacturer recommends an initial dosage of 5 mg once daily in patients 6 years of age and older with decreased renal function (CrCl <= 30 mL/min, including those on hemodialysis) and/or impaired hepatic function. Cetirizine should preferably not be used in children less than 6 years of age with renal and/or hepatic impairment because of the difficulty in reliably administering doses smaller than 2.5 mg (1/2 teaspoonful) and a lack of pharmacokinetic and safety data in this population.


  1. Matzke GR, Yeh J, Awni WM, Halstenson CE, Chung M (1987) "Pharmacokinetics of cetirizine in the elderly and patients with renal insufficiency." Ann Allergy, 59, p. 25-30
  2. Barnes CL, McKenzie CA, Webster KD, Poinsett-Holmes K (1993) "Cetirizine: a new, nonsedating antihistamine." Ann Pharmacother, 27, p. 464-70
  3. Rihoux JP, Mariz S (1993) "Cetirizine. An updated review of its pharmacological properties and therapeutic efficacy." Clin Rev Allergy, 11, p. 65-88
  4. Campoli-Richards DM, Buckley MM, Fitton A (1990) "Cetirizine. A review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria." Drugs, 40, p. 762-81
  5. Awni WM, Yeh J, Halstenson CE, Opsahl JA, Chung M, Matzke GR (1990) "Effect of haemodialysis on the pharmacokinetics of cetirizine." Eur J Clin Pharmacol, 38, p. 67-9
  6. Simons FE, Watson WT, Minuk GY, Simons KJ (1993) "Cetirizine pharmacokinetics and pharmacodynamics in primary biliary cirrhosis." J Clin Pharmacol, 33, p. 949-54
  7. Horsmans Y, Desager JP, Hulhoven R, Harvengt C (1993) "Single-dose pharmacokinetics of cetirizine in patients with chronic liver disease." J Clin Pharmacol, 33, p. 929-32
  8. (2001) "Product Information. Zyrtec (cetirizine)." Pfizer U.S. Pharmaceuticals
View all 8 references

Children's Zyrtec drug interactions

There are 258 drug interactions with Children's Zyrtec (cetirizine).

Children's Zyrtec alcohol/food interactions

There is 1 alcohol/food interaction with Children's Zyrtec (cetirizine).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.