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Calcipotriene topical Disease Interactions

There is 1 disease interaction with calcipotriene topical:

Major

Calcipotriene (Includes Calcipotriene topical) ↔ Hypercalcemia

Severe Potential Hazard, High plausibility

Applies to: Hypercalcemia, Hypervitaminosis D, Poisoning by Vitamins

The use of calcipotriene topical preparations is contraindicated in patients with demonstrated hypercalcemia or evidence of vitamin D toxicity. Calcipotriene is a synthetic vitamin D3 analog. Systemic absorption of topically applied calcipotriene ranges from less than 1% for the scalp solution to 5% to 6% for the ointment. Calcipotriene has been reported to be 100 to 200 times less potent in its effects on calcium utilization than natural vitamin D, which facilitates the absorption of calcium in the intestine. Transient, rapidly reversible elevation of serum calcium has been reported following the topical administration of calcipotriene. If elevation in serum calcium outside the normal range occurs, treatment should be discontinued until normal calcium levels are restored. Patients should be advised to contact their physician if they experience early symptoms of hypercalcemia such as weakness, fatigue, somnolence, headache, anorexia, dry mouth, metallic taste, nausea, vomiting, abdominal cramps, constipation, diarrhea, vertigo, tinnitus, ataxia, exanthema, muscle pain, bone pain, and irritability.

References

  1. Dubertret L, Wallach D, Souteyrand P, Perussel M, Kalis B, Meynadier J, Chevrant-Breton J, Beylot C, Bazex JA, Jurgensen HJ "Efficacy and safety of calcipotriol (MC 903) ointment in psoriasis vulgaris. A randomized, double-blind, right/left comparative, vehicle- controlled study." J Am Acad Dermatol 27 (1992): 983-8
  2. Murdoch D, Clissold SP "Calcipotriol. A review of its pharmacological properties and therapeutic use in psoriasis vulgaris." Drugs 43 (1992): 415-29
  3. Bourke JF, Berth-Jones J, Iqbal SJ, Hutchinson PE "High-dose topical calcipotriol in the treatment of extensive psoriasis vulgaris." Br J Dermatol 129 (1993): 74-6
View all 8 references

calcipotriene topical drug Interactions

There are 134 drug interactions with calcipotriene topical

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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